Ab0493 immunoglobulins After Acute Physical Exercise in Patients With Systemic Lupus Erythematosus

Abstract

BackgroundModerate exercise improves the functions of the immune system. The results of serum immunoglobulins in response to acute physical exercise are conflicting, but in general, there is an increase in serum immunoglobulins in athletes and non-athletes after maximal and submaximal exercise. The effects of acute physical exercise on serum immunoglobulin in patients with systemic lupus erythematosus are unknown.ObjectivesTo determine the serum levels of IgG, IgM and IgA immunoglobulins in patients with systemic lupus erythematosus after a single session of acute aerobic exercise.MethodsThirty-one women with SLE (ACR1997 and/or SLICC 2012 criteria),11 with active lupus and 20 with inactive lupus, and 24 healthy women, who were matched by gender, age, and body mass index, participated in this study. All subjects underwent a maximal exercise test on motorized treadmill, with increases in velocity every minute until exhaustion, to evaluate the speed (km/h), heart rate, Borg scale (6-20), and the reason for stopping the test (fatigue and/or dyspnea). Samples of blood were collected in the morning, after an 8-hour fast and immediately after acute physical activity, and stored in a freezer at -80°C until the tests were performed. Immunoglobulin IgG, IgM and IgA assay was performed by turbitometry according to the manufacturer (Turbiquest, Labtest Diagnostic S.A).ResultsThere was an increase in both IgG and IgA serum levels after physical activity in SLE patients (p = 0.004 for IgG and p = 0.002 for IgA) and healthy controls (p <0.001 for IgG and p <0.001 for IgA) (Figure1). Inactive SLE patients showed higher levels of IgG and IgA after exercise (p = 0.006 and p = 0.010, respectively) (Figure 2), in comparison with the active SLE patients. There was no difference in IgM serum levels before and after the exercise test in both groups.Figure 1 Comparison of IgG, IgM and IgA immunoglobulins intra and inter-group lupus and control δ = AverageFigure 2 Comparison of IgG, IgM and IgA immunoglobulins intra- and inter-group of active and inactive lupus. δ = AverageConclusionPatients with SLE, mainly with inactive disease, responded to acute physical exercise with increased IgG and IgA serum levels, similarly to healthy controls.References[1] Nehlsen-Cannarella SL, et al. The effects of acute moderate exercise on lymphocyte function and serum immunoglobulin levels. Int J Sports Med. 1991; 12(4): 391-398..[2] Nieman DC and Nehlsen-Cannarella SL.The effects of acute and chronic exercise of immunoglobulins. Sports Med. 1991; 11(3): 183-201.[3] Ochoa-Martínez PY, et al. Cinética de la inmunoglobulina-A salival (IgAs) en adultos jóvenes con capacidad aeróbica promedio o excelente antes y después de una prueba de esfuerzo máximo. Revista Chilena de Infectología, 2017; 34: 27-32.Disclosure of InterestsNone declared