AB0482 Dual Neutralization of TNF-α and CXCL10 with Bispecific IGG (IGG-SCFV, MSK–101) is Efficacious in Human TNF Transgenic Mice and LPS-Induced Bone Resorption Model
Abstract:BackgroundTumor necrosis factor-α (TNF-α) is a pivotal cytokine which plays a crucial role in the pathogenesis of rheumatoid arthritis (RA), and monoclonal antibodies targeting TNF-α are widely used in the clinic. However, there is unmet need for non-responders to TNF inhibitor. CXCL10 is a chemokine that is increased in the serum and synovial fluid of RA and important in migration of pro-inflammatory cells and fibroblasts and bone destruction in RA. Anti-CXCL10 monoclonal antibody was reported to be efficacio… Show more
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