Ab0411 cognitive Impairment in Primary Sjögren’s Syndrome: A Case-Control Study

Abstract

Background:Neurological symptoms are common in primary Sjögren’s syndrome (pSS) with a prevalence of 8.5 to 70%, focusing on cognitive impairment, information in pSS is scarce.Many neuropsychological tests are used to diagnose cognitive impairment. The Montreal Cognitive Assessment (MoCA) is a validated, practical, and reliable instrument for screening mild cognitive impairment.Objectives:To evaluate the prevalence of cognitive impairment with the MoCA test in pSS and compare it with controls.Methods:Patients of a rheumatology clinic in Northeastern Mexico were recruited, who met the pSS AECG 2002 or ACR-EULAR 2016 classification criteria. Controls, matched by demographic characteristics were included for comparison. All subjects took the MoCA. The test has a range of 0-30 points, the highest score reflects better cognitive function, and explores 6 cognitive domains (Table 2).Table 1.Demographic and clinical characteristics≤ 9 years of education≥10 years of educationGroupNmean, SD1Min-maxp-valuenmean, SD1Min-maxp-valueMoCA totalpSS1725.65 (2.17)20 - 290.2484626.67 (2.27)20 - 300.3Control1424.36 (3.85)17 - 303627.22 (2.24)21 - 30VisuospatialpSS173.76 (0.9)1 - 50.505464.17 (1.03)2 - 50.056Control144.07 (1.59)0 - 5364.58 (0.87)2 - 5NamingpSS172.82 (0.39)2 - 30.831462.96 (0.2)2 - 30.711Control142.79 (0.57)1 - 3362.97 (0.16)2 - 3Deyaled recallpSS173.06 (1.34)1 - 50.251463.48 (1.31)0 - 50.921Control142.43 (1.65)0 - 5363.44 (1.68)0 - 5AttentionpSS175 (0.79)3 - 60.041465.37 (0.77)4 - 60.285Control144.29 (1.06)3 - 6365.53 (0.56)4 - 6AbstractionpSS171.71(0.68)0 - 20.464461.89 (0.31)1 - 20.79Control141.86 (0.36)1 - 2362 (0.23)1 - 3OrientationpSS176 (0)6 - 60.999465.93 (0.25)5 - 60.083Control146 (0)6 - 6366 (0)6 - 6LanguagepSS172.41(0.71)1 - 30.741462.61 (0.57)1 - 30.878Control142.5 (0.76)1 - 3362.58 (0.84)0 - 31SD: Standard deviationWe defined mild cognitive impairment as a score <26 and moderate-severe cognitive impairment as a score <24 as previously determined in Mexican population.Results:Demographic and clinical characteristics are described in Table 1. Mild cognitive impairment was present in 13 (25.4%) in pSS group versus 14 (27%) in control group. Moderate-severe cognitive impairment was present in 9 (17%) of pSS group versus 8 (15%) in control (p> 0.05).Table 2.MoCA subtest analysis by years of education in pSS and control group.CharacteristicspSSn=51Controln=51Age, Mean (SD)56 (10.4)54 (14)SexFemale n (%)47 (92.15)48 (94)Male n (%)4 (7.85)3 (7.3)Disease duration (years), mean (SD)6.38 (6.15)ESSPRI mean (SD)4.94 (2.28)Years of education, median (q25-q75)13 (10-17)12 (10-15)Employment, mean (%)19 (37)29 (56)Results of the individual domains and comparison between groups are shown in Table 2. Attention was lower in the pSS group with ≤9 years of education compared to the control group (p <0.05).Conclusion:We did not found a difference in the prevalence of cognitive impairment, either mild or moderate-severe, in pSS subjects with low disease duration versus controls by MoCA. We found a lower attention score in the pSS group with less than 10 of years of education.The combination of neuropsychological examining and imaging techniques, such as SPECT or brain MRI, seem a more sensitive way to detect cognitive impairment in earlier stages.References:[1]Manzo, C., Martinez-Suarez, E., Kechida, M., Isetta, M. and Serra-Mestres, J. (2019). Cognitive Function in Primary Sjögren’s Syndrome: A Systematic Review. Brain Sciences, 9(4), p.85.[2]Aguilar-Navarro S, Mimenza-Alvarado A, Palacios-García A, Samudio-Cruz A, Gutiérrez-Gutiérrez L, Ávila-Funes J. Validez y confiabilidad del MoCA (Montreal Cognitive Assessment) para el tamizaje del deterioro cognoscitivo en méxico. Revista Colombiana de Psiquiatría. 2018;47(4):237-243.Disclosure of Interests:None declared