Ab0371 prevalence of Cachexia in a Population of Moroccan Women With Rheumatoid Arthritis

Abstract

BackgroundPrevalence of cachexia in a population of Moroccan women with rheumatoid arthritis.ObjectivesThe objective of our study is to assess body composition in women with rheumatoid arthritis (RA) compared to healthy controls.MethodsWe conducted a case-control study of 112 female patients with rheumatoid arthritis according to ACR/EULAR 2010 Rheumatoid Arthritis Classification Criteria; and 224 healthy women of the same age. Body composition and bone mineral density (BMD) results were obtained by Dual-Energy X-Ray Absorptiometry (DXA). Rheumatoid cachexia (RC) was defined as a Lean mass index (LMI) below the 10th percentile and a Fat mass index (FMI) above the 25th percentile compared with the control group. We performed a comparison between RA patients and healthy controls and then performed multiple regression looking for factors associated with rheumatoid cachexia.ResultsThe prevalence of rheumatoid cachexia was 42.85% while the mean body mass index (BMI) was the same in both groups. RA patients had higher fat mass and lower lean mass compared with healthy controls. In our population, 78.60% of patients were on methotrexate and 12.50% on TNF inhibitor. Comparison between patients with and without CR showed that patients with CR have high disease activity, with the presence of more bone erosions. Regression showed that CR was significantly associated with bone erosions and disease activity (OR at 33.31 (8.42- 131.70) and 8.98 (1.64 - 49.20) respectively) This was independent of age, erythrocyte sedimentation rate, C-reactive protein, duration of disease, cumulative steroid dose, and use of conventional or biologic background therapies.ConclusionOur study showed that nearly half of our RA patients have CR even with high BMI. CR in our work is associated with the presence of high disease activity, and the presence of bone erosions.REFERENCES:NIL.Acknowledgements:NIL.Disclosure of InterestsNone Declared.