AB0302 The role of the biomarker 14–3–3 eta in rheumatoid arthritis: a review

Kilborn, S.; Bukhari, Marwan

doi:10.1136/annrheumdis-2018-eular.6614

Cited by 4 publications

(5 citation statements)

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“…The 14-3-3h-Ab appeared at higher levels in early, treatment naïve RA, while no difference was seen in established RA compared to controls 7 . The 14-3-3h-Ab was not associated with inflammatory markers ESR or CRP 7 . Although higher levels of the 14-3-3h protein were detected in early RA (p<0.05), rate of detection was higher in established RA 2 .…”

Section: Ab0302mentioning

confidence: 69%

“…When combined with current markers RF ±ACPA the detection capacity for early RA increased to 78% and for established RA to 96%, compared to 72% and 88% 4 , respectively for RF ±ACPA alone. Including the 14-3-3h-Ab further increased detection 7 . The 14-3-3h-Ab appeared at higher levels in early, treatment naïve RA, while no difference was seen in established RA compared to controls 7 .…”

Section: Ab0302mentioning

confidence: 99%

“…Including the 14-3-3h-Ab further increased detection 7 . The 14-3-3h-Ab appeared at higher levels in early, treatment naïve RA, while no difference was seen in established RA compared to controls 7 . The 14-3-3h-Ab was not associated with inflammatory markers ESR or CRP 7 .…”

Section: Ab0302mentioning

confidence: 99%

“…Inclusion criteria were confirmed RA, 14-3-3h and English language. Results: Seven key papers were identified on 14-3-3h proteins [1][2][3][4][5][6] and one on 14-3-3h antibodies (14-3-3h-Ab) 7 . Detecting RA: 14-3-3h was elevated in patients with RA compared to healthy controls 2,4 and patients with other diseases (p<0.001) 4 .…”

Section: Ab0302mentioning

confidence: 99%

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AB0303 Ultrasound aspect of posterior tibial tendon in rheumatoid arthritis

Afilal

Rkain

Fellous

et al. 2018

Rheumatoid Arthritis – Prognosis, Predictors and Outcome

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BackgroundPosterior tibial tendon involvement is common in rheumatoid arthritis. Ultrasound has an important place in the examination of this tendon.ObjectivesEvaluate the prevalence of ultrasound signs of posterior tibial tendon involvement in rhumatoid arthritis.MethodsThis is a cross-sectional study that included fourteen consecutive patients (100% female, mean age 55.3 years) with rhumatoid arthritis (median duration of progression of 13.5 years, mean specialised care of 2.1 years). A grey and Doppler ultrasound study was performed on affected feet, looking for effusion, thickening or corporal thinning, hypoechoic aspect, fissures, and Doppler activity in the posterior tibial tendon.Results28 feet were studied with ultrasound evaluation of the posterior tibial tendon. Figure 1 illustrates the prevalence of the pathological aspects of the posterior tibial found on ultrasound examination.Abstract AB0303 – Figure 1Ultrasound aspects of the posterior tibial tendon in patients RAConclusionsThis study illustrates the different pathological aspects of the posterior tibial tendon. It highlights the high prevalence of this tendinopathy in the rheumatoid foot. Ultrasound allows accurate assessment of this tendon in RA patients.A large-scale study compared with a control group is necessary to better interpret and complete these preliminary results.Disclosure of InterestNone declared

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Section: Ab0302mentioning

confidence: 69%

Section: Ab0302mentioning

confidence: 99%

Section: Ab0302mentioning

confidence: 99%

Section: Ab0302mentioning

confidence: 99%

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AB0303 Ultrasound aspect of posterior tibial tendon in rheumatoid arthritis

Afilal

Rkain

Fellous

et al. 2018

Rheumatoid Arthritis – Prognosis, Predictors and Outcome

View full text Add to dashboard Cite

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“…Results: Seven key papers were identified on 14-3-3h proteins 1-6 and one on 14-3-3h antibodies (14-3-3h-Ab) 7 . Detecting RA: 14-3-3h was elevated in patients with RA compared to healthy controls 2,4 and patients with other diseases (p<0.001) 4 .…”

Section: Referencesmentioning

confidence: 99%

AB0301 Serum pyridinoline is associated with radiographic joint erosions in rheumatoid arthritis

Rajalingham¹,

Hashimah²,

Shaharir³

et al. 2018

Rheumatoid Arthritis – Prognosis, Predictors and Outcome

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BackgroundPyridinoline (Pyd) is a 3-hydroxypyridinium derivative which is an intermolecular cross-link compound of type I and II collagen.1 It is a marker of bone resorption based on bone biopsy and radioisotope kinetics studies.2In rheumatoid arthritis (RA), destruction of bones may contribute to increased levels of serum Pyd.ObjectivesThe purpose of this study was to compare the serum pyridinoline (Pyd) levels between RA patients and healthy controls and to determine the correlation of serum Pyd levels with radiographic joint erosions.MethodsThis was a monocentric, cross sectional, case-control study which was conducted from June 2016 to February 2017 at the Universiti Kebangsaan Malaysia Medical Centre (UKMMC). Serum samples were obtained from 48 patients with RA and 48 healthy controls. The enzyme-linked immunosorbent assay (ELISA) method was used for quantitative analysis of serum Pyd. Besides, all the RA patients were assessed for joint damage based on Modified Sharp Score (MSS), disease activity based on the disease activity score in 28-joints (DAS 28) and functional capacity based on Health Assessment Questionnaires Disability Index (HAQ-DI).Abstract AB0301 – Table 1Correlation between serum pyridinoline and other clinical variablesResultsThe median serum Pyd levels was much higher among the RA patients (110.20 ng/mL [92.30–120.64]) compared to the controls (98.22 ng/mL [85.54–111.41]); p<0.05. RA patients with erosive disease had significantly higher serum Pyd levels (p=0.024). There was a significant positive correlation between serum Pyd levels and joint erosion score (r=0.285, p=0.049). The serum Pyd levels had no demonstrable association with disease activity or functional capacity. Neither steroid nor biologic therapy influenced the levels of serum Pyd.ConclusionsRA patients had significantly higher levels of serum Pyd compared to healthy controls. The serum Pyd levels had significant correlation with radiographic joint erosions which reflected disease damage.References[1] Nemoto R, Nakamura I, Nishijima Y, Shiobara K, Shimizu M, Takehara T, et al. Serum pyridinoline crosslinks as markers of tumour-induced bone resorption. Br J Urol. 1997;80:274–80.[2] Plant MJ, Williams AL, O’Sullivan MM, Lewis PA, Coles EC, Jessop JD. Relationship between time-integrated C-reactive protein levels and radiologic progression in patients with rheumatoid arthritis. Arthritis Rheum2000;43:1473–7.AcknowledgementsThe authors would like to thank the Research Committee of UKMMC for funding this research.Disclosure of InterestNone declared

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