Abstract:BackgroundSjögren's syndrome (SS) is a chronic autoimmune disorder in which exocrine dysfunction can lead to chronic, debilitating dryness. Expression studies in SS have identified the dysregulated expression of coding and non-coding transcripts enriched in innate and adaptive immune response pathways.ObjectivesIn our recent SS RNA-seq study, we identified 3748 transcripts showing differential expression (DE; FC>2 or <0.5, q<0.05) in SS patients compared to healthy controls. Of these SS-associated transcripts,… Show more
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