Abstract:BackgroundHigh mobility group box protein 1 (HMGB1) is a nuclear DNA-binding protein that can function as an alarmin when is released from activated and dying cells. In association with nucleosomes, HMGB1 may contribute to the pathogenesis of systemic lupus erythematosus (SLE). Some previous reports have associated HMGB1 with the pathogenesis of cutaneous lupus and lupus nephritis (LN). HMGB1 may also be contained in microparticles (MPs). These vesicles have a wide spectrum of biological activities in intercel… Show more
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