Abstract:BackgroundSalivary glands epithelial cells (SGECs) activation and loss of homeostasis play a key role in primary Sjogren Syndrome (pSS) [1]. High serum and saliva levels of β2-mycroglobulin (β2-M) have been described [2] in pSS, however, the exact origin of this molecule is still unclear. Our preliminary data from single cell analysis on pSS salivary glands treated with immunosuppressors show a downregulation of this protein in SGECs following treatment.ObjectivesAim of this study is to evaluate the expression… Show more
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