Ab0077 semaphorin4b Is Upregulated in Rheumatoid Arthritis Patients and Induces Expression of Inflammatory Mediators by Macrophages and Fibroblast-Like Synoviocytes
Abstract:BackgroundSeveral studies have shown that different semaphorin family members are involved in the pathogenesis of rheumatoid arthritis (RA). On one hand, our group has demonstrated that (Sema)phorin 3B and Sema3F are reduced in RA patients and play a protective role. On the other hand, Sema4A and Sema4D are increased in RA patients and are associated with inflammatory processes (Garcia, 2019; Igea, 2022).ObjectivesThe aim of this study is to determine the role of Sema4B in the pathogenesis of RA.MethodsGene ex… Show more
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