AB0062 Reciprocal interaction between macrophage migration inhibitory factor and interleukin-8 in gout

Kim, H.-R.; Lee, S.-H.; Lee, K.-A.; Kim, K.-W.

doi:10.1136/annrheumdis-2018-eular.2365

Cited by 5 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IL-8 induces chemotaxis in neutrophils, causing them to migrate toward the site of infection and inflammation [ 47 ]. MSU dramatically increases the synthesis of IL-8 mRNA in synovial endothelial cells, which activates and drives neutrophil aggregation, leading to the initiation of acute gouty arthritis inflammation [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models

Sun

Tan

et al. 2022

Nutrients

View full text Add to dashboard Cite

Acute inflammation and hyperuricemia are associated with gouty arthritis. As an edible and therapeutic mushroom, Sanghuangporus vaninii (SV) has an inhibitory effect on tumorigenesis, and Inonotus hispidus (IH) exhibits anti-tumor, anti-inflammatory, and antioxidant properties. In this study, uric acid (UA) and xanthine oxidase (XOD) levels in hyperuricemic mice were examined to determine the regulatory effects of SV and IH. SV and IH reversed the pathogenic state of elevated UA levels in the serum and reduced levels of XOD in the serum and liver of mice with hyperuricemia. SV and IH affected the inflammatory response in rats with acute gouty arthritis. Compared to vehicle-treated rats, monosodium urate crystals (MSU) increased the swelling ratio of the right ankle joints. SV and IH administration significantly reduced swelling and inflammatory cell infiltration. SV reduced the levels of interleukin-8 (IL-8) and chemokine ligand-2 (CCL-2), whereas IH reduced the levels of matrix metalloproteinase-9 (MMP-9), CCL-2, and tumor necrosis factor-α (TNF-α), which were confirmed in articular soft tissues by immunohistochemistry. In summary, our data provide experimental evidence for the applicability of SV and IH in gouty arthritis and hyperuricemia treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models

Sun

Tan

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

“… 12–15 A Korean research team discovered that the pro-inflammatory factor macrophage migration inhibitory factor (MIF) and IL-8 in peripheral blood and synovial fluid of gout patients were conformably higher than normal controls. 16 This finding indicated that we can evaluate the levels of inflammatory cytokines in the synovial fluid based on their levels in peripheral blood to determine whether gout is in the acute phase. Nevertheless, the diagnostic efficacy of peripheral inflammatory cytokines in acute gout remains little known.…”

Section: Introductionmentioning

confidence: 99%

Joint Application of Multiple Inflammatory Cytokines in Diagnosis of Gout Flare

Yu¹,

Xue²,

Yu³

et al. 2023

JIR

View full text Add to dashboard Cite

Purpose This study aimed to explore the accuracy for joint application of inflammatory cytokines in diagnosis of gout flare by comparison with peripheral blood cells. Methods We collected the clinical data of 96 acute gout patients and 144 remission gout patients, and compared the levels of peripheral blood cells, inflammatory cytokines and blood biochemistry indexes between acute and remission gout. We respectively assessed the area under curves (AUCs) for single and multiple inflammatory cytokines including C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α), and single and multiple peripheral blood cells including platelet (PLT), white blood cell (WBC), percentages of neutrophils (N%), lymphocytes (L%), eosinophils (E%), basophils (B%) in diagnosis of acute gout by receiver operating characteristic (ROC) curve analysis. Results By contrast with remission gout, the levels of PLT, WBC, N%, CRP, IL-1β, IL-6 and TNF-α increased, and the levels of L%, E% and B% decreased in acute gout. The AUCs of PLT, WBC, N%, L%, E% and B% in diagnosis of acute gout were respectively 0.591, 0.601, 0.581, 0.567, 0.608 and 0.635, while the AUC for joint application of these peripheral blood cells was 0.674. Moreover, the AUCs of CRP, IL-1β, IL-6 and TNF-α in diagnosis of acute gout were respectively 0.814, 0.683, 0.622 and 0.746, while the AUC for joint application of these inflammatory cytokines was 0.883, reflecting significantly higher levels than peripheral blood cells. Conclusion The joint application of multiple inflammatory cytokines can better distinguish acute gout from remission gout compared with peripheral blood cells.

show abstract

“…The components of synovial fluid are closely related to the pathogenesis of gout. High levels of cytokines such as interleukin 1 (IL-1 β ), IL-63, IL-85, and tumor necrosis factor α (TNF α ) have been detected in the synovial fluid of gout patients [ 5 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

The Diagnostic Value of Synovial Fluid Lymphocytes in Gout Patients

Huang

Guo

et al. 2021

Disease Markers

View full text Add to dashboard Cite

Objective. This study is aimed at investigating the diagnostic value of synovial fluid cell counts in gout patients. Methods. A total of 185 gout, 64 rheumatoid arthritis (RA), 26 axial spondyloarthritis (axSpA), and 24 osteoarthritis (OA) patients were included in the study. According to serum uric acid (sUA) levels on attack, gout patients were divided into normal sUA gout patients and high sUA gout patients. The laboratory data were recorded. ROC curves were generated to evaluate the diagnostic value of the variables for gout patients and normal sUA gout patients compared with RA, axSpA, and OA patients. Results. The synovial fluid white blood cell (WBC), peripheral blood mononuclear cell (PBMC), monocyte, polymorphonuclear (PMN), and neutrophil counts in gout patients were higher than those in OA patients ( P < 0.05 ). The synovial fluid PBMC and lymphocyte counts in gout patients were lower than those in RA and axSpA patients ( P < 0.05 ). ROC curve results showed that the AUC values of lymphocytes and sUA for gout patients were 0.728 and 0.881, respectively, which were higher than those of other variables. The optimal cutoff value of lymphocytes for gout was 1.362, with a Youden index of 0.439, a sensitivity of 83.3%, and a specificity of 60.6%. The AUC values of lymphocytes, sUA, and CRP for normal sUA gout patients were 0.694, 0.643, and 0.700, respectively, which were higher than those of other variables. The optimal cutoff value of lymphocytes for normal sUA gout patients was 1.362, with a Youden index of 0.422, a sensitivity of 81.6%, and a specificity of 60.6%. Conclusions. The synovial fluid cell counts of gout patients were different from those of RA, axSpA, and OA patients. Synovial fluid lymphocytes had a higher diagnostic value for gout.

show abstract

AB0062 Reciprocal interaction between macrophage migration inhibitory factor and interleukin-8 in gout

Cited by 5 publications

References 0 publications

Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models

Anti-Gouty Arthritis and Anti-Hyperuricemia Properties of Sanghuangporus vaninii and Inonotus hispidus in Rodent Models

Joint Application of Multiple Inflammatory Cytokines in Diagnosis of Gout Flare

The Diagnostic Value of Synovial Fluid Lymphocytes in Gout Patients

Contact Info

Product

Resources

About