2022
DOI: 10.1136/annrheumdis-2022-eular.1544
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Ab0048 the Suppression of Inflammatory Processes and Modulation of Mapk Signaling by Shikonin Derivatives in Primary Oa Chondrocytes

Abstract: BackgroundOsteoarthritis (OA) is one of the most common joint disorders and is characterized by the degeneration and loss of articular cartilage with chronic arthritis of the joint edge and subchondral bone. OA is causally influenced by several factors, including age, gender, familial susceptibility, as well as local biomechanics, cartilage cell apoptosis, and the action of degenerative enzymes. Despite intensive research, there are still few effective therapeutic approaches.ObjectivesIn the rat OA model, shik… Show more

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