Scientific Abstracts 2023
DOI: 10.1136/annrheumdis-2023-eular.3578
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Ab0034 next Generation Sequencing and Shikonin Effects on Human Primary Articular Osteoarthritis Chondrocytes

Abstract: BackgroundOsteoarthritis (OA) is one of the most common joint disorders, leading to functional disability, especially in people aged over 50 years, causing loss to the economy and affecting social development [1]. Drugs addressing the underlying biological causes of OA are not currently available [2].ObjectivesNaturally occurring naphthoquinone derivatives, such as shikonin and derivatives thereof, were shown to inhibit inflammatory processes and chondrocyte apoptosis by regulating the PI3K/AKT pathway in a ra… Show more

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