AB0030 Cytokine Profiles in Systemic Lupus Erythematosus and Rheumatoid Arthritis

Abstract

BackgroundOur aim was to compare serum levels of cytokines in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).ObjectivesComparative data on cytokine profile in SLE and rheumatoid arthritis RA patients are scarce.MethodsWe examined serum samples from 80 pts with SLE, median and interquartile range (25th–75th percentile) of disease duration 48 (2–432) months; age 31,5 (16–65) years; 72 female; 74 pts with RA, disease duration 90,0 (30,00–192,0) months; age 54,0 (44,0–62,0) years; 59 female, and 28 healthy donors. Cytokine analyses were performed with Bio-Plex® technology (Human Grp I Cytokine 27-plex panel).ResultsPts with SLE had significantly lower levels of IL-1β, -1ra, -2, -9, eotaxin, G-CSF, IFN-γ, MIP-1β, TNF-α, VEGF and higher levels of IL-4, -6, -8, -12, GM-CSF, MCP-1, PDGF-BB, RANTES than healthy donors. Compared to RA, cytokine/chemokine levels from SLE were significantly different. The concentrations of IL-1β, -1ra, -2, -5, -6, -7, -9, -10, -13, 15, eotaxin, FGF, G-CSF, IFN-γ, IP-10, MIP-1α, TNF-α, VEGF in SLE were significantly lower than RA. The concentrations of IL-4, -8, MCP-1, MIP-1β, PDGF-BB, RANTES was higher in the SLE cohort (Table 1).ConclusionsSerum concentration of most proinflammatory, Th-2 related, bone marrow–derived cytokines, stromal cells and angiogenic factors in SLE pts is substantially lower than in healthy donors and pts witch RA. These data demonstrate significantly higher chemokine levels in SLE versus RA.ReferencesChun HY, Chung JW, Kim HA, Yun JM, Jeon JY, Ye YM, Kim SH, Park HS, Suh CH. Cytokine IL-6 and IL-10 as biomarkers in systemic lupus erythematosus. J Clin Immunol. 2007; 27(5):461–6.Kokkonen H, Söderström I, Rocklöv J, Hallmans G, Lejon K, Rantapää Dahlqvist S. Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum. 2010; 62(2):383–91. doi: 10.1002/art.27186.Sieber J, Daridon C, Fleischer SJ, Fleischer V, Hiepe F, Alexander T, Heine G, Burmester GR, Fillatreau S, Dörner T. Active systemic lupus erythematosus is associated with a reduced cytokine production by B cells in response to TLR9 stimulation. Arthritis Res Ther. 2014;16(6):477. doi: 10.1186/s13075-014-0477-1.Disclosure of InterestNone declared

Immunoprofiling of cytokines, chemokines, and growth factors in female patients with systemic lupus erythematosus– a pilot study

“…Eotaxin and MIP-1α levels were not significantly different between groups. However, a study by Novikov et al showed that the expression of otaxin and MIP-1α was significantly lower in patients with SLE than in those with rheumatoid arthritis (RA) group [ 31 ].…”

Association of Circulating Vascular Endothelial Growth Factor Levels With Autoimmune Diseases: A Systematic Review and Meta-Analysis

“…Among 241 eligible studies meeting the inclusion criteria, 76 articles were excluded due to unextractable data, insufficient data on HCs, irrelevant VEGF sample type (urine/synovial fluid/tear fluid), or inappropriate disease control groups. Finally, 165 studies were included in the meta-analysis, with 28, 29, 40, 13, 8, 12, 16, 23, and six studies on SLE ( 20 , 21 , 26 – 51 ), RA ( 12 , 22 – 24 , 38 , 43 , 52 – 74 ), SSc ( 11 , 38 , 39 , 64 , 75 – 110 ), BD ( 111 – 123 ), KD ( 18 , 124 – 130 ), AS ( 55 , 73 , 131 – 140 ), IBD ( 141 – 156 ), PsA ( 12 , 14 , 135 , 136 , 157 – 175 ) and GD ( 10 , 176 – 180 ), respectively. The main study characteristics are summarized in Table 1 and Appendix 1 .…”

Genetically predicted associations between circulating cytokines and autoimmune diseases: a bidirectional two-sample Mendelian randomization

“…Additionally, chemokines, a category of chemoattractant cytokines, contribute significantly to the pathogenesis of SLE and its complications, notably lupus nephritis ( 58 ). The research by Novikov A, et al., indicates a notably lower expression of Eotaxin in the SLE group compared to those with rheumatoid arthritis ( 59 ), highlighting the unique inflammatory profiles in these conditions. IL-22RA1, an essential component of the IL-22 receptor complex, has been observed to decrease in serum and plasma levels as reported by Cheng and Pan ( 60 , 61 ).…”