Ab Interno Trabeculectomy: Development of a Novel Device (Trabectome???) and Surgery for Open-Angle Glaucoma

Francis, Brian A.; See, Robert F.; Rao, Narsing A.; Minckler, Don S.; Baerveldt, George

doi:10.1097/01.ijg.0000196653.77836.af

Cited by 134 publications

(80 citation statements)

References 17 publications

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“…Since 2006, the Trabectome®, a device used to perform an ab interno trabeculectomy, has been used in glaucoma surgery [12,13]. The trabecular meshwork is removed by electroablation, resulting in an increased aqueous outflow to the opened Schlemm's canal.…”

Section: Introductionmentioning

confidence: 99%

Trabeculectomy ab interno with the Trabectome® as a therapeutic option for uveitic secondary glaucoma

Anton

Heinzelmann

Neß

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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Section: Introductionmentioning

confidence: 99%

Trabeculectomy ab interno with the Trabectome® as a therapeutic option for uveitic secondary glaucoma

Anton

Heinzelmann

Neß

et al. 2015

Graefes Arch Clin Exp Ophthalmol

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“…Developed by Neomedix (Tustin, CA, USA) more than a decade ago [9], the Trabectome ablates 60-120 degrees of TM and the inner wall of Schlemm's canal by high-frequency electrosurgery [17]. The Trabectome provides active irrigation and aspiration, which maintains better stability and temperature in the anterior chamber, compared with passive chamber management [18].…”

Section: Introductionmentioning

confidence: 99%

“…These procedures reduce IOP by different mechanisms: 1) ablate or bypass the trabecular meshwork (TM) using instruments such as the Trabectome (Neomedix Corporation, Tustin, CA, USA) [9][10][11], iStent (Glaukos Corp., Laguna Hills, CA, USA) [12], or the Hydrus mini-stent (Ivantis Inc., Irvine, CA, USA) [13]; 2) establish a new route for suprachoroidal drainage (CyPass Micro-Stent; Transcend Medical, Menlo Park, CA, USA [14]; 3) reduce the production of aqueous humor [15]; or 4) create a subconjunctival filtration route [16].…”

Section: Introductionmentioning

confidence: 99%

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

Dang¹,

Wang²,

Cen³

et al. 2018

Preprint

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To evaluate the 2-year efficacy and safety of ab interno trabeculectomy with the Trabectome in Chinese primary open-angle glaucoma (POAG) patients. This was a multicenter, retrospective study and included POAG patients with or without visually-significant cataracts. The primary outcome was intraocular pressure (IOP) reduction. Secondary outcomes included reduction of glaucoma medications, surgical complications, and success at 2-years. Success was defined as: 1) IOP < 21 mmHg and at least 20% IOP reduction from baseline after 3 months at any two consecutive visits, and 2) no additional glaucoma surgery required. A total of 42 patients were enrolled; thirteen had a history of failed glaucoma surgery. Twelve patients underwent Trabectome surgery combined with phacoemulsification while the remainder underwent Trabectome surgery alone. Overall, the mean preoperative IOP was 21.4±1.23 mmHg. The Trabectome lowered IOP to 18.5± 0.94 mmHg at 2 years (P<0.05). The number of glaucoma medications also decreased from a baseline of 2.0±0.9 to 1.2± 0.21 at 2 years (P=0.04). The overall success was 78%, with patients undergoing combined surgery having a higher success than those with Trabectome surgery alone (100% vs. 76%). No major complications were seen. The Trabectome appears to be an efficient and safe procedure in Chinese POAG patients in the longterm.

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“…The management strategies for HP include early initiation of aqueous suppressant treatment after AGV implantation [16] , steroid injection at the time surgery [17] , antimetabolites, digital massage [18] , bleb needling, and surgical excision of the bleb [8] . While GDDs bypass the conventional outflow, the Trabectome surgical system (NeoMedix, Tustin, CA, USA) enhances the conventional outflow [19] . It has a long track record of safety and efficacy in different types and severity of glaucoma [20,21] .…”

Section: Introductionmentioning

confidence: 99%

Impact of same-session trabectome surgery on Ahmed glaucoma valve outcomes

Esfandiari

Shazly

Shah

et al. 2018

Graefes Arch Clin Exp Ophthalmol

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Purpose: To evaluate the efficacy and survival rates of same session ab interno trabeculectomy with the trabectome and Ahmed glaucoma valve implant (AT) in comparison to the Ahmed glaucoma valve alone (A).Method : A total of 107 eyes undergoing primary glaucoma surgery were enrolled in this retrospective comparative case series, including 48 eyes which underwent AT and 59 eyes which received A alone . Participants were identified using the procedural terminology codes, and their medical records were reviewed. The primary outcome measure was surgical success, defined as intraocular pressure (IOP) > 5 mmHg, ≤ 21 mmHg, and IOP reduction ≥ 20% from baseline at two consecutive visits after three months, no reoperation for glaucoma. Secondary outcome measures were IOP, the number of glaucoma medications, incidence of a hypertensive phase, and best corrected visual acuity (BCVA). Results:The cumulative probability of success at one year was 70% in AT, and 65% in A (p=0.85). IOP decreased significantly from 26.6 ± 10.1 mmHg at baseline to 14.7 ± 3.3 mmHg at the final follow-up in AT (p= 0.001). The corresponding numbers for A were 28.8 ± 10.2 and 16.7 ± 4.9, respectively (p= 0.001). The final IOP was significantly lower in AT (p= 0.022). The number of medications at baseline was comparable in both groups (2.6 ± 1.2 in AT and 2.5 ± 1.3 in A, p=0.851). Corresponding number at 1 year visit was 1.2±2 in AT and 2.8±1.8 in A (p=0.001).The incidence of a hypertensive phase was 18.7% in AT and 35.5% in A (p=0.05). HP resolved in only 30% of eyes. The criteria for HP resolution were fulfilled in 9 eyes (30%). There was no difference in the rate of resolution of the hypertensive phase between AT and A (33.3% and 28.5%, respectively, p=0.67).Conclusion : Ahmed glaucoma valve implant with same session trabectome surgery significantly decreased the rate of the hypertensive phase and postoperative IOP as well as the number of glaucoma medications.

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Ab Interno Trabeculectomy: Development of a Novel Device (Trabectome???) and Surgery for Open-Angle Glaucoma

Cited by 134 publications

References 17 publications

Trabeculectomy ab interno with the Trabectome® as a therapeutic option for uveitic secondary glaucoma

Trabeculectomy ab interno with the Trabectome® as a therapeutic option for uveitic secondary glaucoma

Two-Year Outcomes of Ab Interno Trabeculectomy with the Trabectome for Chinese Primary Open Angle Glaucoma: A Retrospective Multicenter Study

Impact of same-session trabectome surgery on Ahmed glaucoma valve outcomes

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