AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6

Mj, Agajanian; Mp, Walker; Ad, Axtman; Rr, Ruela-de-Sousa; Ad, Rabinowitz; Dm, Graham; Ryan, Meagan B.; Ds, Serafin; Bennett, James M.; Rm, Couñago; Dh, Drewry; Jm, Elkins; Gileadi, C.; Gileadi, O.; Ph, Godoi; Kapadia, Nirav; Müller, Susanne; As, Santiago; Fj, Sorrell; Wells, Carrow; Fedorov, Oleg; Tm, Willson; Wj, Zuercher; Mb, Major

doi:10.1101/258632

Cited by 3 publications

(3 citation statements)

References 56 publications

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“…The binding of NECAP recruits SNX9 for the late stages of CCP formation. In another study, 106 AAK1 phosphorylates the μ2 subunit of AP2 to promote CME of LRP6 in WNT signaling (Figure 10D).…”

Section: Intracellular Ensmentioning

confidence: 90%

Enzymatic Noncovalent Synthesis

et al. 2020

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Enzymatic reactions and noncovalent (i.e., supramolecular) interactions are two fundamental nongenetic attributes of life. Enzymatic noncovalent synthesis (ENS) refers to a process where enzymatic reactions control intermolecular noncovalent interactions for spatial organization of higher-order molecular assemblies that exhibit emergent properties and functions. Like enzymatic covalent synthesis (ECS), in which an enzyme catalyzes the formation of covalent bonds to generate individual molecules, ENS is a unifying theme for understanding the functions, morphologies, and locations of molecular ensembles in cellular environments. This review intends to provide a summary of the works of ENS within the last decade and emphasize ENS for functions. After comparing ECS and ENS, we describe a few representative examples where nature uses ENS, as a rule of life, to create the ensembles of biomacromolecules for emergent properties/functions in a myriad of cellular processes. Then, we focus on ENS of man-made (synthetic) molecules in cell-free conditions, classified by the types of enzymes. After that, we introduce the exploration of ENS of man-made molecules in the context of cells by discussing intercellular, peri/intracellular, and subcellular ENS for cell morphogenesis, molecular imaging, cancer therapy, and other applications. Finally, we provide a perspective on the promises of ENS for developing molecular assemblies/processes for functions. This review aims to be an updated introduction for researchers who are interested in exploring noncovalent synthesis for developing molecular science and technologies to address societal needs.

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Section: Intracellular Ensmentioning

confidence: 90%

Enzymatic Noncovalent Synthesis

et al. 2020

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“…165 Therefore, it can be concluded that clathrin clears the LRP6 receptor from the plasma membrane. 166 6.3. Notch Signaling Pathway.…”

Section: Wnt Signaling Pathwaymentioning

confidence: 99%

Food-Derived Peptides: Beneficial CNS Effects and Cross-BBB Transmission Strategies

Li,

Dang,

Wang

et al. 2023

J. Agric. Food Chem.

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“…68 Further studies focused on the development of selective NAK inhibitors are needed to improve the knowledge around the NAK family members and to confirm their potential as broad-spectrum antivirals. In this regard, the use of chemical probes such SGC-GAK1 69 (32, Figure 5) or SGC-AAK-1 70,71 (33, Figure 5) will be of utmost importance. It is also noteworthy that the structurally related negative controls, 34 and 35, are available (Figure 5).…”

Section: Journal Of Medicinal Chemistrymentioning

confidence: 99%

Kinase Inhibitors as Underexplored Antiviral Agents

et al. 2021

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Viral infections are a major health problem; therefore, there is an urgent need for novel therapeutic strategies. Antivirals used to target proteins encoded by the viral genome usually enhance drug resistance generated by the virus. A potential solution may be drugs acting at host-based targets since viruses are dependent on numerous cellular proteins and phosphorylation events that are crucial during their life cycle. Repurposing existing kinase inhibitors as antiviral agents would help in the cost and effectiveness of the process, but this strategy usually does not provide much improvement, and specific medicinal chemistry programs are needed in the field. Anyway, extensive use of FDA-approved kinase inhibitors has been quite useful in deciphering the role of host kinases in viral infection. The present perspective aims to review the state of the art of kinase inhibitors that target viral infections in different development stages.

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AAK1 inhibits WNT signaling by promoting clathrin-mediated endocytosis of LRP6

Cited by 3 publications

References 56 publications

Enzymatic Noncovalent Synthesis

Enzymatic Noncovalent Synthesis

Food-Derived Peptides: Beneficial CNS Effects and Cross-BBB Transmission Strategies

Kinase Inhibitors as Underexplored Antiviral Agents

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