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Abstract

Urinary tract infections (UTIs) are caused by presence and growth of microorganisms anywhere in UT, which is an important cause of morbidity and mortality. Most cases of UTIs are caused by Enterobacteriacea especially Escherichia coli (E. coli), Klebsiella species and Enterobacter species. The study ascertained the incidence of Bacteriuria in pregnant women with special reference to E. coli. This prospective longitudinal study was carried out over a period of two years in Nair Hospital, Mumbai, Subjects were 3000 married pregnant women and 300 non-pregnant women. Collection, transportation and Culturing of urine samples was carried out by standard procedures. Identification of the isolate was done on the basis of morphological, cultural characteristics and Rapid Biochemical Identification Kit. E. coli strains were identified by motility and KB003 Hi25 TM Enterobactriaceae Identification Kit. Antibiotic susceptibility testing of hundred and eleven E. coli isolates obtained from urine samples was carried out by Kirby -Bauer disk diffusion method, E. coli was the principal pathogen in pregnant and in non-pregnant women, both, Among the E. coli isolates, 84% were sensitive to Piperacillin + Tazobactum followed by to Nitrofurantoin (73%). Around 50% of these strains were found to be sensitive to Norfloxacin, Ceftriaxone, Cefotaxime and Amikacin while remaining were found to be resistant to Ampicillin, Augmentin, Nalidixic acid, Cephalexin, and Cefuroxime. In order to prevent development of resistance, antibiotic susceptibility patterns must be continuously and periodically evaluated to select the appropriate regimen to treat UTI and to avoid complications in pregnancy.