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Abstract

Introduction:The relationship between serum vitamin D3 (25-OH-Cholecalciferol) and anti-double stranded-DNA (ds-DNA) antibodies in systemic lupus erythematosus (SLE) has been revealed separately; however, a possible link between these two factors and its effect on disease severity in patients with SLE has not been clarified yet. This is the first study investigating the conjoint association of vitamin D3 (VD 3 ) and anti-ds-DNA antibodies on disease activity in Bahraini patients with SLE. Objectives:To evaluate serum VD3 and anti-ds-DNA antibodies as important factors in clinical status in adult Bahraini patients with SLE and to look into the possible correlation between these two factors and their relation to disease activity in this patient's group. Material and methods:Fifty-one Bahraini SLE patients (mean age of 40.8 years, females were 84.3%) followed at Salmanyia Medical Complex in the period between 2016-2018 were included in this retrospective longitudinal (two-time points) study. Only patients who had blood samples that were taken before (baseline) and after oral VD 3 therapy and had anti-ds-DNA antibodies and serum uric acid tested at the same time-point with vitamin D 3 were included. The vitamin D therapy was VD3 tablet 50.000 IU once per week for 3months. Blood samples were obtained at any time between 2-3 months after starting the therapy for determination of serum levels of vitamin D, anti-ds-DNA antibodies, UA, complements (C 3 &C 4 ), but also for calcium, phosphorus, alkaline phosphatase (ALP), parathyroid hormone (PTH), C-reactive protein (CRP) and antinuclear antibodies (ANA). Results:The current study showed that VD therapy bring about two-fold increment in its mean serum level (P<0.0001) with increased serum calcium (P<0.05). Wonderfully, the mean serum levels of ds-DNA auto-antibodies and UA were significantly decreased after VD therapy (p=0.015 and p=0.010, respectively). Interestingly, when the group was segregated by gender and age; the female group and the age group<40 years, independently, showed statistically significant difference in all parameters exactly as the whole group. Conclusion:We evaluated serum levels of anti-ds-DNA antibody and vitamin D as important factors in SLE disease. Our study showed strong inverse correlation between these two factors, thus, the correction of hypovitaminosis D resulted in reduced serum ds-DNA auto antibodies. The current study established the inverse correlation between vitamin D 3 and the disease activity as measured by anti-ds-DNA antibody levels in adult Bahraini patients with SLE. Consequently, we strongly recommend continuous vitamin D 3 supplementation for Bahraini patients with SLE. Citation: Hassan AB, Farid E, Jaradat AA, et al. Correction of hypovitaminosis d lead to reduction of anti-double-stranded DNA antibody levels in Bahraini patients with systemic lupus erythematosus. Citation: Hassan AB, Farid E, Jaradat AA, et al. Correction of hypovitaminosis d lead to reduction of anti-double-stranded DNA antibody levels in Bahraini patients w...