“…In the tumor microenvironment, these properties are thought to shape the communication between cancer, stromal and immune cells, thereby influencing numerous cellular processes during cancer progression such as cell proliferation, motility, angiogenesis, metastasis or immune responses [2,16]. In both normal and cancer tissues, intercellular contacts mediated by epithelial members of the CEACAM family have also been implicated in apoptosis [24], cell migration [25,26], vascular remodeling [27] and morphogenesis. Interestingly, a number of CEACAMs present in the digestive tract are also used as anchoring points by several intestinal pathogens including pathogenic Escherichia coli [28,29], Moraxella catarrhalis [30,31], Haemophilus influenzae [31], Helicobacter pylori [32] and several neisserial strains [33].…”