Abstract:Background and objectives
Musculoskeletal presentations following initial HIV infection, although variable, cause significant morbidity. gp120 is a HIV surface glycoprotein and plasmacytoid dendritic cells (pDCs) are one of the first cells to encounter gp120 aided by their high expression of CD4. pDCs produce large amounts of interferon alpha (IFN-alpha) following Toll like receptor (TLR) stimulation and their role in rheumatic disease is of increasing interest with IFN-alpha being implicated in subsets of inf… Show more
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