A1H,13C,31P and15N NMR study of (pyrrolidine-2,2-diyl)bisphosphonic acid, tetraalkyl(pyrrolidine-2,2-diyl)bisphosphonates and acyclic tetraethyl bisphosphonates

Olive, Gilles; Genderen, Marcel H. P. van

doi:10.1002/1097-458x(200005)38:5<379::aid-mrc638>3.0.co;2-d

Cited by 9 publications

(5 citation statements)

References 8 publications

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“…The cheaper instrument cost is another advantage of MS-based analysis over the NMR-based metabolomics approach. [15][16][17][18][19][20][21][22][23][24][25][26][27][28] Metabolomic strategies cover two approaches "untargeted discovery global" and "targeted validation tandem." 14,29 Untargeted discovery metabolomics is based on a hypothesis-generating approach.…”

Section: Introductionmentioning

confidence: 99%

“…NMR spectroscopy is a highly reproducible, high‐throughput and non‐invasive tool for structural determination and quantitative analyses of metabolites in vitro and in vivo 18,19 . Proton nuclear magnetic resonance spectroscopy ( 1 H NMR) has been widely used for metabolomics due to its robust nature, natural abundance and minimal sample preparation 20–24 . The major disadvantage of NMR spectroscopy is its lower sensitivity compared to MS‐based techniques, with its detection limits ranging between micromolar to sub‐micromolar levels.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, MS‐based analysis requires a small sample volume (as low as 10 µL) compared to NMR spectroscopy. The cheaper instrument cost is another advantage of MS‐based analysis over the NMR‐based metabolomics approach 15–28 …”

Section: Introductionmentioning

confidence: 99%

“… 18 , 19 Proton nuclear magnetic resonance spectroscopy ( 1 H NMR) has been widely used for metabolomics due to its robust nature, natural abundance and minimal sample preparation. 20 , 21 , 22 , 23 , 24 The major disadvantage of NMR spectroscopy is its lower sensitivity compared to MS‐based techniques, with its detection limits ranging between micromolar to sub‐micromolar levels. However, recent developments in cryoprobes, nanoprobes and high magnetic field spectrometers have increased the sensitivity and resolution of NMR, increasing the number of detectable metabolites.…”

Section: Introductionmentioning

confidence: 99%

“…The cheaper instrument cost is another advantage of MS‐based analysis over the NMR‐based metabolomics approach. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 …”

Section: Introductionmentioning

confidence: 99%

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Metabolomics of neurological disorders in India

Gupta

Sharma

2021

Analytical Science Advances

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Metabolomics is the comprehensive study of the metabolome and its alterations within biological fluids and tissues. Over the years, applications of metabolomics have been explored in several areas, including personalised medicine in diseases, metabolome‐wide association studies (MWAS), pharmacometabolomics and in combination with other branches of omics such as proteomics, transcriptomics and genomics. Mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy are the major analytical techniques widely employed in metabolomics. In addition, MS is coupled with chromatography techniques like gas chromatography (GC) and liquid chromatography (LC) to separate metabolites before analysis. These analytical techniques have made possible identification and quantification of large numbers of metabolites, encompassing characterization of diseases and facilitating a systematic and rational therapeutic strategy based on metabolic patterns. In recent years, the metabolomics approach has been used to obtain a deeper insight into the underlying biochemistry of neurodegenerative disorders and the discovery of biomarkers of clinical implications. The current review mainly focuses on an Indian perspective of metabolomics for the identification of metabolites and metabolic alterations serving as potential diagnostic biomarkers for neurological diseases including acute spinal cord injury, amyotrophic lateral sclerosis, tethered cord syndrome, spina bifida, stroke, Parkinson's disease, glioblastoma and neurological disorders with inborn errors of metabolism.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…The cheaper instrument cost is another advantage of MS‐based analysis over the NMR‐based metabolomics approach. 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 …”

Section: Introductionmentioning

confidence: 99%

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