“…Since the discovery that adult human somatic cells can be reprogrammed into induced pluripotent stem cells (iPSC) by overexpression of only four transcription factors (Takahashi et al, 2007), a new era of research has started. Recently, numerous studies using iPSC-derived neurons have been published, including iPSC-derived neurons to model neurodegenerative diseases (Israel et al, 2012;Mattis et al, 2012;Kaye and Finkbeiner, 2013;Ryan et al, 2013;Richard and Maragakis, 2014). These proof-of principle studies recapitulate the key aspects of the different pathologies, including aberrant synaptic abnormalities and functional deficits (Penzes et al, 2011;Hick et al, 2014;Wen et al, 2014).…”