A λ-dynamics investigation of insulinWakayamaand other A3 variant binding affinities to the insulin receptor
Monica P. Barron,
Jonah Z. Vilseck
Abstract:Insulin Wakayama is a clinical insulin variant where a conserved valine at the third residue on insulin's A chain (ValA3) is replaced with a leucine (LeuA3), impairing insulin receptor (IR) binding by 140-500 fold. This severe impact on binding from such a subtle modification has posed an intriguing problem for decades. Although experimental investigations of natural and unnatural A3 mutations have highlighted the sensitivity of insulin-IR binding to minor changes at this site, an atomistic explanation of thes… Show more
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