A Zwitterionic Copolymer as Rheology Modifier and Fluid Loss Agents for Water-Based Drilling Fluids

Tan, Xianfeng; Duan, Lijie; Han, Weichao; Liu, Ying; Guo, Mingyi

doi:10.3390/polym13183120

Cited by 21 publications

(15 citation statements)

References 30 publications

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“…antifouling, 23,24,27 responding to stimuli, 28,29 lubricating, 30,31 self-healing, 32 antibacterial, 24 and biosensing. 33,34 Due to their great tolerance to highly saline environments, 9 they have remarkable potential to be applied as ionomers, 35,36 fibers, 6 and rheology modifiers, 37,38 drug/gene delivery vehicles, 2,5,39,40 analogues of important biological structures, 6,41 and anti(bio)fouling materials. 15,42,43 In addition to their outstanding antifouling property, zwitterionic materials can also enhance biocompatibility, reduce immune response, promote cellular uptake of chemical drugs/genes, and prolong the circulation time.…”

Section: Introductionmentioning

confidence: 99%

“…(Poly)zwitterions can be manufactured into different structural forms: brushes, − films, hydrogels, − particles, membranes, and coatings, with different functions, e.g. antifouling, ,, responding to stimuli, , lubricating, , self-healing, antibacterial, and biosensing. , Due to their great tolerance to highly saline environments, they have remarkable potential to be applied as ionomers, , fibers, and rheology modifiers, , drug/gene delivery vehicles, ,,, analogues of important biological structures, , and anti(bio)fouling materials. ,, In addition to their outstanding antifouling property, zwitterionic materials can also enhance biocompatibility, reduce immune response, promote cellular uptake of chemical drugs/genes, and prolong the circulation time. , Zwitterionic modifications could also provide various special functions when applied as drug carriers, such as stimuli-responsive and tumor targeting abilities . A summary of (poly)zwitterion platforms applied in drug delivery is presented in Table .…”

Section: Introductionmentioning

confidence: 99%

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Modeling Polyzwitterion-Based Drug Delivery Platforms: A Perspective of the Current State-of-the-Art and Beyond

Nikkhah

Vandichel

2022

ACS Eng. Au

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Drug delivery platforms are anticipated to have biocompatible and bioinert surfaces. PEGylation of drug carriers is the most approved method since it improves water solubility and colloid stability and decreases the drug vehicles’ interactions with blood components. Although this approach extends their biocompatibility, biorecognition mechanisms prevent them from biodistribution and thus efficient drug transfer. Recent studies have shown (poly)zwitterions to be alternatives for PEG with superior biocompatibility. (Poly)zwitterions are super hydrophilic, mainly stimuli-responsive, easy to functionalize and they display an extremely low protein adsorption and long biodistribution time. These unique characteristics make them already promising candidates as drug delivery carriers. Furthermore, since they have highly dense charged groups with opposite signs, (poly)zwitterions are intensely hydrated under physiological conditions. This exceptional hydration potential makes them ideal for the design of therapeutic vehicles with antifouling capability, i.e., preventing undesired sorption of biologics from the human body in the drug delivery vehicle. Therefore, (poly)zwitterionic materials have been broadly applied in stimuli-responsive “intelligent” drug delivery systems as well as tumor-targeting carriers because of their excellent biocompatibility, low cytotoxicity, insignificant immunogenicity, high stability, and long circulation time. To tailor (poly)zwitterionic drug vehicles, an interpretation of the structural and stimuli-responsive behavior of this type of polymer is essential. To this end, a direct study of molecular-level interactions, orientations, configurations, and physicochemical properties of (poly)zwitterions is required, which can be achieved via molecular modeling, which has become an influential tool for discovering new materials and understanding diverse material phenomena. As the essential bridge between science and engineering, molecular simulations enable the fundamental understanding of the encapsulation and release behavior of intelligent drug-loaded (poly)zwitterion nanoparticles and can help us to systematically design their next generations. When combined with experiments, modeling can make quantitative predictions. This perspective article aims to illustrate key recent developments in (poly)zwitterion-based drug delivery systems. We summarize how to use predictive multiscale molecular modeling techniques to successfully boost the development of intelligent multifunctional (poly)zwitterions-based systems.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Modeling Polyzwitterion-Based Drug Delivery Platforms: A Perspective of the Current State-of-the-Art and Beyond

Nikkhah

Vandichel

2022

ACS Eng. Au

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“…For example, the zwitterionic polymer PADAD maintains a filtration volume of less than 10 mL under 2 mol/L NaCl or 0.1 mol/L CaCl 2 contamination. 32 The quaternary copolymer (AM/AMPS/AHPS/AAc tetrapolymer) prepared by Sanam et al can maintain low fluid loss under saturated NaCl pollution but did not investigate the performance under high-concentration Ca 2+ pollution. 33 Similarly, the quaternary copolymers studied by Li et al can also maintain a low filtration volume under saturated NaCl contamination, 34 but investigations on Ca 2+ contamination are still lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Although there have been studies considering the salt resistance of polymer fluid loss agents, they are mostly limited to low concentrations of salt/calcium. For example, the zwitterionic polymer PADAD maintains a filtration volume of less than 10 mL under 2 mol/L NaCl or 0.1 mol/L CaCl 2 contamination . The quaternary copolymer (AM/AMPS/AHPS/AAc tetrapolymer) prepared by Sanam et al can maintain low fluid loss under saturated NaCl pollution but did not investigate the performance under high-concentration Ca 2+ pollution .…”

Section: Introductionmentioning

confidence: 99%

An Inverse Emulsion Polymer as a Highly Effective Salt- and Calcium-Resistant Fluid Loss Reducer in Water-Based Drilling Fluids

Shan

Jiang

et al. 2022

ACS Omega

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To control the fluid loss of water-based drilling fluids (WBDFs) in salt-gypsum formations, a nano-SiO 2 graft copolymer was prepared by inverse emulsion polymerization. The polymer (EAANS) was prepared with acrylamide, 2-acrylamido-2-methyl-1-propane sulfonic acid, N-vinylpyrrolidone, and KH570-modified nano-silica (M-SiO 2 ) as raw materials. The molecular structure and morphology of EAANS were characterized by Fourier transform infrared spectroscopy, nuclear magnetic resonance, thermogravimetric analysis, transmission electron microscopy (TEM), and other methods. In the temperature range of 150 °C, 2 wt % EAANS can reduce the API filtration volume of the base slurry to within 20 mL and the HP-HT filtration volume at 150 °C to 21.8 mL. More importantly, 2 wt % EAANS can maintain the API filtration volume less than 10 mL even when the concentration of NaCl or CaCl 2 was as high as 36 or 30 wt %, and as the salt/calcium content increased, the amount of filtration continued to decrease. The results of TEM, X-ray diffraction, particle size distribution, and scanning electron microscopy showed that the fluid loss control mechanism of EAANS was that EAANS can form a crosslinked network structure in the solution and adsorb on the clay surface, so as to reduce the particle size of clay particles, increase the proportion of fine particles in drilling fluids, and finally form a dense filter cake to reduce the filtration volume. Because of the excellent filtration performance of EAANS at high Na + /Ca 2+ concentration, EAANS can become a promising WBDF fluid loss reducer in salt-gypsum formations.

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“…Drilling fluids, known as the blood of drilling, are essential for stabilizing the wellbore, carrying cuttings, and cooling and lubricating the drillbit during the drilling process [ 1 , 2 , 3 ]. Generally, drilling fluids can be divided into water-based drilling fluids (WBDFs), oil-based drilling fluids (OBDFs), and foam drilling fluids, according to their composition [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Nano-Modified Polymer Gels as Temperature- and Salt-Resistant Fluid-Loss Additive for Water-Based Drilling Fluids

Sun

et al. 2022

Gels

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With the continuous exploration and development of oil and gas resources to deep formations, the key treatment agents of water-based drilling fluids face severe challenges from high temperatures and salinity, and the development of high temperature and salt resistance filtration reducers has always been the focus of research in the field of oilfield chemistry. In this study, a nano-silica-modified co-polymer (NS-ANAD) gel was synthesized by using acrylamide, isopropylacrylamide, 2-acrylamide-2-methyl propane sulfonic acid, diallyl dimethyl ammonium chloride, and double-bond-modified inorganic silica particles (KH570-SiO2) through free radical co-polymerization. The introduction of nanotechnology enhances the polymer’s resistance to high temperature degradation, making it useful as a high-temperature-resistant fluid loss reducer. Moreover, the anions (sulfonates) and cations (quaternary ammonium) enhance the extension of the polymer and the adsorption on the surface of bentonite particles in a saline environment, which in turn improves the salt resistance of the polymer. The drilling fluids containing 2.0 wt% NS-ANAD co-polymer gels still show excellent rheological and filtration performance, even after aging in high temperature (200 °C) and high salinity (saturated salt) environments, showing great potential for application in deep and ultra-deep drilling engineering.

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A Zwitterionic Copolymer as Rheology Modifier and Fluid Loss Agents for Water-Based Drilling Fluids

Cited by 21 publications

References 30 publications

Modeling Polyzwitterion-Based Drug Delivery Platforms: A Perspective of the Current State-of-the-Art and Beyond

Modeling Polyzwitterion-Based Drug Delivery Platforms: A Perspective of the Current State-of-the-Art and Beyond

An Inverse Emulsion Polymer as a Highly Effective Salt- and Calcium-Resistant Fluid Loss Reducer in Water-Based Drilling Fluids

Nano-Modified Polymer Gels as Temperature- and Salt-Resistant Fluid-Loss Additive for Water-Based Drilling Fluids

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