A Zonal Comparison of MIB1-Ki67 Immunoreactivity in Benign and Malignant Melanocytic Lesions

Li, Ling-Xi L.; Crotty, Kerry A.; McCarthy, Stanley W.; Palmer, A. W.; Kril, Jillian J.

doi:10.1097/00000372-200012000-00002

Cited by 128 publications

(71 citation statements)

References 37 publications

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“…16,17,22,41 Nagasaka et al 16 found that all Spitz nevi had a relatively low MIB-1 index (mean 3.2%), which was significantly lower than that of malignant melanoma (mean 15.3%). Similarly, Kanter-Lewensohn et al 17 found an average MIB-1 index of 4% in Spitz nevi and 29.7% in malignant melanoma and Bergman et al 22 reported 1.5% for Spitz nevi vs 14.9% for malignant melanoma.…”

Section: Discussionmentioning

confidence: 99%

Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis

et al. 2005

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A subset of Spitz nevi poses substantial diagnostic difficulty, even among experts, due to its resemblance to malignant melanoma. These lesions are termed atypical Spitz nevi/tumors and there is currently a lack of objective criteria for predicting their biologic behavior. We compared the expression of Ki-67, p21, and fatty acid synthase by immunohistochemistry in 10 atypical Spitz nevi, 28 typical Spitz nevi, 19 compound melanocytic nevi and 18 invasive malignant melanomas. There was a progressive increase in fatty acid synthase cytoplasmic expression with statistically significant differences observed between Spitz nevi and atypical Spitz nevi (P ¼ 0.003) and between atypical Spitz nevi and malignant melanoma (Po0.050). Ki-67 nuclear staining was lower in both typical and atypical forms of Spitz lesions than in malignant melanoma (Po0.001). The degree of P21 nuclear expression in atypical Spitz nevi was not significantly different than in Spitz nevi, but was significantly greater than expression in conventional nevi and approached significance after multiple comparisons corrections for malignant melanoma. Thus, a high level of P21 expression makes a tumor more likely to be a typical or atypical Spitz nevus than a malignant melanoma, especially when coupled with a low Ki-67 index and weak expression of fatty acid synthase. These immunohistochemical observations support the concept that atypical Spitz nevi are distinct lesions of borderline biologic behavior residing between Spitz nevi and malignant melanoma. The study also compared a large array of histologic features of 16 cases of typical Spitz nevi in children with 12 typical Spitz nevi in adults. The adult lesions were significantly more likely to be intradermal and to display dermal fibroplasia, but were histologically similar to their pediatric counterparts in all other respects.

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Section: Discussionmentioning

confidence: 99%

Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis

et al. 2005

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“…Immunohistochemical staining with Ki-67, [31][32][33][34] Ki-67 and bcl-2, 35 and proliferating cell nuclear antigen 36,37 has shown some promise in discrim-inating melanoma from benign nevi, including Spitz nevi. In situ hybridization to detect expression of melastatin, 38 a melanocyte specific gene that is expressed in melanoma at levels inversely proportional to metastatic rates, is useful in predicting metastasis and disease free survival in adult patients with melanoma 39 and may be useful in predicting which atypical spitzoid lesion may be malignant.…”

Section: Discussionmentioning

confidence: 99%

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Fullen

Sondak

et al. 2003

Cancer

146

122

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A new device—the rotational particle separator (RPS)—is compared to the cyclone for the removal of ultrafine particles, such as cryogenically condensed contaminant droplets from natural gas. The comparison focusses on identifying for each configuration the smallest size of particle which has a 50% chance of being removed from the gas stream. Whereas a cyclone can only separate 1 μm droplets at very low‐throughputs on the order of 1 MMscfd, at the same energy consumption and device volume, the rotational particle separator removes droplets of that size at throughputs of 300 MMscfd. The advantage of the rotational particle separator, therefore, lies in its compact separation potential for full‐scale industrial gas well throughputs. © 2006 American Institute of Chemical Engineers AIChE J, 2007

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“…[3][4][5] Within this broad field, the study of the physiological and transcriptional differences between more superficial and deeper melanoma cells has emerged as an active area of research. [6][7][8] Our study aims to contribute to the understanding of intralesional differences in protein expression by malignant cells.…”

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confidence: 99%

Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma

et al. 2010

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Cell surface expression of glucose-regulated protein 78 (GRP78) occurs in several types of cancer; however, its role in the behavior of primary cutaneous melanoma is not well studied. The association of cell surface GRP78 with other proteins such as MTJ1 stimulates cell proliferation. In this study, we characterized the pattern of expression of GRP78 and MTJ1 in invasive primary cutaneous melanomas and analyzed the relationships between the pattern of expression and various clinicopathological parameters. We found two patterns of GRP78 expression in invasive primary cutaneous melanoma. One pattern showed a gradual fading of protein expression from superficial to deeper levels within the same tumor. The second pattern of expression showed a similar fading with an abrupt regaining of expression at the deep invasive edge of the melanoma. These two distinct patterns of GRP78 expression correlated with both patient survival and depth of tumor invasion. A moderate MTJ1 expression was found to be associated with decreased patient survival; however, no significant associations were observed between patterns of GRP78 and MTJ1 expression. Our study (1) describes two distinct patterns of GRP78 in invasive primary cutaneous melanoma, (2) inversely correlates regain of GRP78 expression with patient survival, and (3) suggests a modifying effect of MTJ1 on GRP78 in enhancing tumor aggressiveness.

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A Zonal Comparison of MIB1-Ki67 Immunoreactivity in Benign and Malignant Melanocytic Lesions

Cited by 128 publications

References 37 publications

Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis

Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis

Sentinel lymph node biopsy for patients with problematic spitzoid melanocytic lesions

Patterns of GRP78 and MTJ1 expression in primary cutaneous malignant melanoma

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