A Zn-doped etch-and-rinse adhesive may improve the mechanical properties and the integrity at the bonded-dentin interface

Toledano, Manuel; Sauro, Salvatore; Cabello, Inmaculada; Watson, Timothy F.; Osorio, Raquel

doi:10.1016/j.dental.2013.04.024

Cited by 80 publications

(82 citation statements)

References 48 publications

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“…This finding is in accordance with those of previous research that claimed that addition of some amount of zinc oxide nanoparticles would enhance the mechanical properties of various dental materials (15)(16)(17). Indeed, the mechanical improvement by nano-ZnO is related to their very small size that leads to a good distribution of these nanoparticles between the larger particles, producing a higher density of filler in a specified area (9).…”

Section: Discussionsupporting

confidence: 82%

Evaluating the Physical Properties of Novel Zinc Phosphate and Zinc Polycarboxylate Cements Containing Zinc Oxide Nanoparticles

Hemmati

Hamze²,

Fatemi³

et al. 2017

Avicenna J Dent Res

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Background: Zinc oxide (ZnO) that is a main component of Zinc Polycarboxylate and Zinc Phosphate conventional cements has been incorporated into many dental materials for mechanical enhancement. Moreover, by decreasing the particle size of ZnO down to nano-scale, its beneficial effects would tremendously increase because the nanoparticles have considerably higher surface to volume ratio compared to micro-particles. Objectives: The aim of this study was to assess mechanical, physical, and chemical properties of Zinc Polycarboxylate and Zinc Phosphate cements containing Zinc oxide nanoparticles. Methods: Three powder formulations were prepared for either of the cements based on the nanoparticles content (0 wt%, 10 wt% before, and 10 wt% after sintering the powder). The prepared groups were compared with each other in terms of their compressive strength, setting time, film thickness, and acid erosion resistance using one way ANOVA and Tukey HSD statistical tests (α = 0.05). Results: Incorporating zinc oxide nanoparticles did not significantly change neither the film thickness nor the acid erosion resistance of the cements (P > 0.05). Nevertheless, the setting time of zinc phosphate significantly decreased by adding nanoparticles (P < 0.05) while there was no statistical difference in zinc polycarboxylate groups (P > 0.05). On the other hand, although incorporating nanoparticles significantly reduced the compressive strength of zinc phosphate (P < 0.05), it was noticeably improved in zinc polycarboxylate groups (P < 0.05). Conclusions: By incorporating 10 wt% of nano zinc oxide into zinc phosphate and zinc polycarboxylate cements, their compressive strength are more affected rather than their setting time, film thickness, and acid erosion resistance.

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Section: Discussionsupporting

confidence: 82%

Evaluating the Physical Properties of Novel Zinc Phosphate and Zinc Polycarboxylate Cements Containing Zinc Oxide Nanoparticles

Hemmati

Hamze²,

Fatemi³

et al. 2017

Avicenna J Dent Res

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“…Zinc has been demonstrated to reduce MMPs-mediated collagen degradation (Osorio et al, 2011), to inhibit dentin demineralization (Takatsuka et al, 2005) and to induce dentin remineralization at the bonded interface (Toledano et al, 2013a). Zinc influences signaling pathways and stimulates a metabolic effect in hard tissue mineralization (Hoppe et al, 2011) and remineralization processes (Barcellos et al, 2016;Lynch et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Toledano

Osorio

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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The aim of this study was to evaluate changes in the mechanical and chemical behavior, and bonding ability at dentin interfaces infiltrated with polymeric nanoparticles (NPs) prior to resin application. Dentin surfaces were treated with 37% phosphoric acid followed by application of an ethanol suspension of NPs, Zn-NPs or Ca-NPs followed by the application of an adhesive, Single Bond (SB). Bonded interfaces were stored for 24 h, submitted to microtensile bond strength test, and evaluated by scanning electron microscopy. After 24 h and 21 d of storage, the whole resin-dentin interface adhesive was evaluated using a Nano-DMA. Complex modulus, storage modulus and tan delta (δ) were assessed. AFM imaging and Raman analysis were performed. Bond strength was not affected by NPs infiltration. After 21 d of storage, tan δ generally decreased at Zn-NPs/resin-dentin interface, and augmented when Ca-NPs or non-doped NPs were used. When both Zn-NPs and Ca-NPs were employed, the storage modulus and complex modulus decreased, though both moduli increased at the adhesive and at peritubular dentin after Zn-NPs infiltration. The phosphate and the carbonate peaks, and carbonate substitution, augmented more at interfaces promoted with Ca-NPs than with Zn-NPs after 21 d of storage, but crystallinity did not differ at created interfaces with both ions-doped NPs. Crosslinking of collagen and the secondary structure of collagen improved with Zn-NPs resin-dentin infiltration. Ca-NPs-resin dentin infiltration produced a favorable dissipation of energy with minimal stress concentration trough the crystalline remineralized resin-dentin interface, causing minor damage at this structure.

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“…Significant increases in Young's modulus were encountered at the hybrid layer, when using the experimental zinc-NPs, and it did not occur in the other experimental groups, corroborating the previously described findings after trichrome staining and the dye-assisted CLSM analysis of these bonded interfaces. It is meaningful, even when values did not reach the level of natural mineralized or intact dentin [32]. The association between mineral precipitation and metalloproteinases inhibition induced by zinc doped adhesives has been previously published.…”

Section: Discusionmentioning

confidence: 99%

Zinc-modified nanopolymers improve the quality of resin–dentin bonded interfaces

et al. 2016

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Demineralized collagen fibers at the hybrid layer are susceptible of degradation.Remineralization may aid to improve bond longevity. Objectives: to infiltrate zinc and calcium-loaded polymeric nanoparticles into demineralized dentin to facilitate hybrid layer remineralization. Materials and Methods: Zinc or calcium-loaded polymeric nanoparticles were infiltrated into etched dentin and Single Bond adhesive was applied.Bond strength was tested after 24 hours and six months storage. Nanomechanical properties, dye-assisted confocal laser microscopy and Masson's trichrome staining evaluation were performed to assess for the hybrid layer morphology, permeability and remineralization ability after 24 hours and three months. Data were analyzed by ANOVA and Student-Newman-Keuls multiple comparisons tests (p<0.05). Results:Immediate bond strength was not affected by nanoparticles infiltration (25 to 30 MPa), while after 6 months bond strengths were maintained (22 to 24 MPa). After 3 months, permeability occurred only in specimens in which nanoparticles were not infiltrated.Dentin remineralization, at the bottom of the hybrid layer, was observed in all groups.After microscopy analysis, zinc-loaded nanoparticles were shown to facilitate calcium deposition throughout the entire hybrid layer. Young's modulus at the hybrid layer increased from 2.09 to 3.25 GPa after 3 months, in specimens with zinc nanoparticles; meanwhile, these values were reduced from 1.66 to 0.49 GPa, in the control group.Conclusions: Infiltration of polymeric nanoparticles into demineralized dentin increased long-term bond strengths. Zinc-loaded nanoparticles facilitate dentin remineralization within the complete resin-dentin interface. Clinical Relevance: Resin-dentin bond longevity and dentin remineralization at the hybrid layer were facilitated by zinc-loaded nanoparticles.

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A Zn-doped etch-and-rinse adhesive may improve the mechanical properties and the integrity at the bonded-dentin interface

Cited by 80 publications

References 48 publications

Evaluating the Physical Properties of Novel Zinc Phosphate and Zinc Polycarboxylate Cements Containing Zinc Oxide Nanoparticles

Evaluating the Physical Properties of Novel Zinc Phosphate and Zinc Polycarboxylate Cements Containing Zinc Oxide Nanoparticles

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Zinc-modified nanopolymers improve the quality of resin–dentin bonded interfaces

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