A zinc(II)–glycine complex is an effective inducer of metallothionein and removes oxidative stress

Hashimoto, Masaki; Ochiai, Yasunobu; Okano, Yasuaki; Yagami, Akiko; Akamatsu, Hirohiko; Matsunaga, Kayoko; Suzuki, Keiichiro

doi:10.1016/j.jdermsci.2006.08.009

Cited by 16 publications

(12 citation statements)

References 11 publications

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“…Regarding the functions of zinc in the suppression of photoageing, zinc compounds have been found to reduce the UVA‐induced generation of reactive oxygen species in the skin of hairless mice, thereby exhibiting a protective effect against UVA‐induced skin damage [18, 19]. Zinc also exerts a protective effect against UVB‐induced tissue damage, i.e., a zinc (II)‐glycine complex reportedly reduces oxidative stress by inducing metallothionein expression [20]. Most of all, zinc induces the synthesis of sodium‐dependent l ‐ascorbic acid transporter and α1(I) procollagen in osteoblasts [21].…”

Section: Introductionmentioning

confidence: 99%

Zinc l‐pyrrolidone carboxylate inhibits the UVA‐induced production of matrix metalloproteinase‐1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis

Takino

Okura

Kitazawa

et al. 2011

Intern J of Cosmetic Sci

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Reduced collagen matrix in the dermis constitutes one of the characteristic features of chronologically aged skin, which is further enhanced on the sun-exposed portions of the body by chronic ultraviolet light (UV) irradiation, inducing the unique changes associated with skin photoageing. The zinc salt of l-pyrrolidone carboxylate (Zinc PCA) has long been used as a cosmetic ingredient, because of its astringent and anti-microbial properties. In the present study, by employing cultured normal human dermal fibroblasts, we found that Zinc PCA suppressed UVA-induced activation of activator protein-1 (AP-1) and reduced matrix metalloproteinase-1 production in these cells, which is thought to be involved in collagen degradation in photoaged skin. Moreover, Zinc PCA treatment of the cells increased the expression of an ascorbic acid transporter mRNA, SVCT2, but not SVCT1, resulting in the enhanced production of type I collagen. Based on these in vitro findings, we consider Zinc PCA to be a promising candidate for an anti-skin ageing agent.

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Section: Introductionmentioning

confidence: 99%

Zinc l‐pyrrolidone carboxylate inhibits the UVA‐induced production of matrix metalloproteinase‐1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis

Takino

Okura

Kitazawa

et al. 2011

Intern J of Cosmetic Sci

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“…For this reason, research on diabetes therapy and prevention has focused a lot of attention on the oxidative stress mechanisms involved, as well as the prevention of these by antioxidants. Zinc (Zn) and it's involvement in the production of the antioxidant methallothionein (MT), has attracted much attention in diabetic research [7,59,66,99]. As reviewed by Chausmer [20], and Tallman and Taylor [82], clinical and epidemiological studies suggest that reduced Zn status is associated with diabetes.…”

Section: Introductionmentioning

confidence: 99%

Diabetes, metallothionein, and zinc interactions: A review

Islam

Loots

2007

BioFactors

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Epidemiological evidence, associating diabetes with zinc (Zn) deficiencies, has resulted in numerous research studies describing the effects of Zn and associated metallothionein (MT), on reducing diabetic complications associated with oxidative stress. MT has been found to have a profound effect on the reduction of oxidative stress induced by the diabetic condition. Over expression of MT in various metabolic organs has also been shown to reduce hyperglycaemia-induced oxidative stress, organ specific diabetic complications, and DNA damage in diabetic experimental animals, which have been further substantiated by the results from MT-knockout mice. Additionally, supplementation with Zn has been shown to induce in vivo MT synthesis in experimental animals and to reduce diabetes related complications in both humans and animal models. Although the results are promising, some caution regarding this topic is however necessary, due to the fact that the majority of the studies done have been animal based. Hence more human intervention trials are needed regarding the positive effects of MT and Zn before firm conclusions can be made regarding their use in the treatment of diabetes.

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“…In fact, we reported that a conditioned medium prepared from UVB‐irradiated keratinocytes stimulates MMP‐1 synthesis and secretion . Furthermore, MMP‐1 synthesis is abolished by treatment with zinc glycine, which enhances intra‐cellular antioxidant defense systems, in keratinocytes before UVB irradiation . Recent papers reported that C. japonica leaf extract reduces MMP‐1 mRNA expression in human dermal fibroblasts .…”

Section: Discussionmentioning

confidence: 99%

Anti‐photoaging capability of antioxidant extract from Camellia japonica leaf

Mizutani

Hashimoto

2014

Experimental Dermatology

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It is well known that the Camellia japonica leaf exhibits antioxidant activity because of its high content of polyphenolic compounds. Thus, the extract prepared from mature leaves of C. japonica (CJML) has been widely used as an anti-ageing material in foods and cosmetics. Concerning the process of growing C. japonica, it is expected that the extract from green leaves (CJGL) has superior effects compared with that from mature leaves. However, there are few reports that discuss the difference between green and mature leaves. In this study, both CJML and CJGL were extracted with 50% 1,3-butylene glycol (1,3-BG) and used for investigations. In a chemical examination, we compared both extracts in terms of scavenging activities against hydrogen peroxide (H2 O2 ) and hydroxyl radicals. CJGL exhibited higher scavenging activities against both types of ROSs compared with CJML. In addition, CJGL reduced the carbonylation of tape-stripped stratum corneum (SC) after UVB irradiation. In a biological study, the intra-cellular ROS level of HaCaT keratinocytes precultured with CJGL for 24 h was significantly lower than that of the control cells. Furthermore, cell damage induced by H2 O2 exposure was attenuated by 24 h precultivation with CJGL but not by 2 h precultivation. The results of examinations indicate that CJGL possess properties that reduce oxidative stress. In addition, the result of 2 h precultivation with CJGL suggests that CJGL might affect the status of intra-cellular antioxidants.

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A zinc(II)–glycine complex is an effective inducer of metallothionein and removes oxidative stress

Cited by 16 publications

References 11 publications

Zinc l‐pyrrolidone carboxylate inhibits the UVA‐induced production of matrix metalloproteinase‐1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis

Zinc l‐pyrrolidone carboxylate inhibits the UVA‐induced production of matrix metalloproteinase‐1 by in vitro cultured skin fibroblasts, whereas it enhances their collagen synthesis

Diabetes, metallothionein, and zinc interactions: A review

Anti‐photoaging capability of antioxidant extract from Camellia japonica leaf

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