“…Functional pathway analysis (Fig. 2b [18]) revealed how a network of clock genes [23–25] – including Per1, Per3, circadian associated repressor of transcription, basic helix‐loop–helix protein 40 and aralkylamine N ‐acetyltransferase – were linked to a large number of synaptic‐regulating genes – Calcium calmodulin‐dependent protein kinases (Camk2a, Camk2d) [26], small GTPase Rab8b [27, 28], intracellular calcium‐binding protein (Calb2) [29], cholecystokinin [30, 31], metabotropic glutamate receptor 2 [32], N ‐methyl‐ d ‐aspartate (NMDA) receptor subunit 2a (Grin2a) [33], Double C2 Domain Beta [34, 35] and membrane‐associated guanylate kinase scaffold proteins [36] (Mpp3, Mpp4) – via a hub of GC‐regulated genes, including Per1[17], Kruppel like factor 9 [37, 38], GC‐induced leucine zipper TSC Domain family member (Tsc22d3) [39] and Calcium calmodulin‐dependent protein kinase 2A (Camk2a) [40], with additional functional inputs from the transcription factor Zinc finger protein 189 [41]. Tetratricopeptide Repeat, Ankyrin Repeat And Coiled‐Coil Containing 1 gene that encodes a post‐synaptic density‐associated scaffolding protein [42] was also an intrinsic link in the network [18].…”