A Young Female With Refractory Hypertension

Nassiri, Nima; Maas, Marissa; Fichtenbaum, Eric J.; Aron, Monish

doi:10.1016/j.urology.2019.09.033

Cited by 3 publications

(3 citation statements)

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“…At the very least, abdominal and pelvic imaging is useful to exclude EPO‐secreting tumors or conditions inducing local renal hypoxia. Other EPO‐secreting tumors associated with erythrocytosis can be seen in Table 1, 4–6,8–28 and include meningiomas, uterine leiomyomas, and parathyroid adenomas 1 …”

Section: Commentarymentioning

confidence: 99%

“…CNS [8][9][10][11] Cerebellar hemangioma Cerebral hemangioblastoma Neuroblastoma Meningioma Gastrointestinal [12][13][14][15] Hepatocellular carcinoma Colon adenocarcinoma Pancreatic carcinoid tumor Hepatic hemangioma Renal [4][5][6][16][17][18][19][20] Renal cell carcinoma Wilms tumor Benign renal tumors (metanephric adenoma, renal hemangioblastoma, reninoma, embryonal adenoma, nephrogenic adenofibroma)…”

Section: Management Of Erythrocytosis Differs Significantly Depending Onmentioning

confidence: 99%

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Erythropoietin‐secreting metanephric adenoma presenting as erythrocytosis

Liu,

Kremyanskaya,

Mehrazin

et al. 2023

American J Hematol

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Section: Commentarymentioning

confidence: 99%

Section: Management Of Erythrocytosis Differs Significantly Depending Onmentioning

confidence: 99%

Erythropoietin‐secreting metanephric adenoma presenting as erythrocytosis

Liu,

Kremyanskaya,

Mehrazin

et al. 2023

American J Hematol

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“…75 Tumors most commonly occur in the second to fourth decades (range: 6 to 72 y) with a female preference of 2:1 (Table 1). 1,75 Presentation is almost always uncontrollable hypertension, hyperaldosteronism, and hypokalemia secondary to renin secretion, 76,77 although some cases may be nonfunctioning. 78 Behavior is indolent, with only very rare exceptions.…”

Section: Clinical Findings and Prognosismentioning

confidence: 99%

Key Renal Neoplasms With a Female Predominance

Baniak

Barletta

Hirsch

2021

Advances in Anatomic Pathology

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Renal neoplasms largely favor male patients; however, there is a growing list of tumors that are more frequently diagnosed in females. These tumors include metanephric adenoma, mixed epithelial and stromal tumor, juxtaglomerular cell tumor, mucinous tubular and spindle cell carcinoma, Xp11.2 (TFE3) translocation-associated renal cell carcinoma, and tuberous sclerosis complex (somatic or germline) associated renal neoplasms. The latter category is a heterogenous group with entities still being delineated. Eosinophilic solid and cystic renal cell carcinoma is the best-described entity, whereas, eosinophilic vacuolated tumor is a proposed entity, and the remaining tumors are currently grouped together under the umbrella of tuberous sclerosis complex/ mammalian target of rapamycin-related renal neoplasms. The entities described in this review are often diagnostic considerations when evaluating renal mass tissue on biopsy or resection. For example, Xp11.2 translocation renal cell carcinoma is in the differential when a tumor has clear cell cytology and papillary architecture and occurs in a young or middle-aged patient. In contrast, tuberous sclerosis complex-related neoplasms often enter the differential for tumors with eosinophilic cytology. This review provides an overview of the clinical, gross, microscopic, immunohistochemical, genetic, and molecular alterations in key renal neoplasms occurring more commonly in females; differential diagnoses are also discussed regardless of sex predilection.

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A case of atypical reninoma with mild hypertension and normal plasma renin activity but elevated plasma renin concentration

Wang

Ding

et al. 2022

BMC Endocr Disord

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Background Reninoma is a rare, benign renal neoplasm. Typical clinical features include severe hypertension, secondary hyperaldosteronism, hypokalaemia and metabolic alkalosis caused by the overproduction of renin. Case presentation A 25-year-old lean Chinese woman with no family history of hypertension was hospitalized for stage 1 hypertension that gradually developed over two years. Endocrine investigation showed hyperreninemia without hyperaldosteronism and hypokalaemia. Interestingly, although the patient had an elevated plasma renin concentration (PRC), her plasma renin activity (PRA) was in the normal range. Abdominal contrast-enhanced computed tomography (CT) scanning revealed a solid, low-density, renal cortical mass with delayed enhancement. Selective renal vein sampling (SRVS) was performed, and a lateralization of the renin secretion from the left kidney was found. Enucleation of the tumour led to a rapid remission of hypertension and hyperreninemia. Based on pathological findings, the patient was diagnosed with reninoma. Immunohistochemical staining of the tumour was positive for Renin, CD34, Vimentin, and synaptophysin (Syn) and negative for somatostatin receptor 2 (SSTR2) and chromogranin A (CgA). Conclusions Reninoma can present as mild hypertension without hyperaldosteronism and hypokalaemia. The clinical features of reninoma may depend on the degree of activation of the renin-angiotensin-aldosterone system (RAAS). PRC should be incorporated in the differential diagnosis of secondary hypertension.

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A Young Female With Refractory Hypertension

Cited by 3 publications

References 0 publications

Erythropoietin‐secreting metanephric adenoma presenting as erythrocytosis

Erythropoietin‐secreting metanephric adenoma presenting as erythrocytosis

Key Renal Neoplasms With a Female Predominance

A case of atypical reninoma with mild hypertension and normal plasma renin activity but elevated plasma renin concentration

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