A YAC Contig Spanning a Cluster of Human Type III Receptor Protein Tyrosine Kinase Genes (PDGFRA-KIT-KDR) in Chromosome Segment 4q12

Spritz, Richard A.; Strunk, Kathleen M.; Lee, Seung Taek; Lu-Kuo, Jennifer M.; Ward, David C.; Paslier, Denis Le; Altherr, Michael R.; Dorman, Thomas E.; Moir, Donald T.

doi:10.1006/geno.1994.1405

Cited by 53 publications

(26 citation statements)

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“…Expression of the longer spliced form of Flt4 as a chimera with the extracellular domain of the CSF-1 receptor shows that the Flt4 intracellular domain can signal a ligand-dependent, growth response in rodent fibroblasts (28,29). Flt4 has been localized to human chromosome 5q34-q35 (25,26); Fltl and Flkl are located at 13q12 (30) and 4ql2 (31,32).…”

mentioning

confidence: 99%

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

Lee¹,

Gray²,

Yuan³

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

349

213

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mentioning

confidence: 99%

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

Lee¹,

Gray²,

Yuan³

et al. 1996

Proc. Natl. Acad. Sci. U.S.A.

349

213

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“…It was suggested that the upregulation of PDGFRα by FGF-β, IL-1β and TGF-β contributes to cellular hyperplasia of bronchial smooth muscles during chronic airway inflammation in asthma [9]. Using short tandem repeats (STR) markers in whole genome linkage disequilibrium mapping, we found that allele frequencies of several STR markers were significantly associated with childhood asthma [10], in which the PDGFRA gene is located at chromosome 4q12 between two statistically significant STR markers, D4S2971 and D4S1592, found in earlier reports by us [10, 11]. …”

Section: Introductionmentioning

confidence: 73%

Variant in Promoter Region of Platelet-Derived Growth Factor Receptor-α (PDGFRα) Gene Is Associated with the Severity and Allergic Status of Childhood Asthma

Tan

Wang

et al. 2006

Int Arch Allergy Immunol

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Background: Upregulation of the platelet-derived growth factor receptor-α (PDGFRα) in airway myofibroblast cells is one of the mechanisms of airway remodeling. The genetic association between PDGFRα promoter polymorphism and severity of childhood asthma was examined. Methods: Five single nucleotide polymorphisms (SNPs) at the promoter regions of the PDGFRα gene were genotyped in 277 unrelated allergic and nonallergic asthmatic children and 93 age-matched controls. Promoter haplotypes were constructed using SNP genotyping data. The serum level of PDGF-AA, the ligand for PDGFRα, was assayed by ELISA kits. Results: The genotype distribution of SNP rs1800810 (–1171G/C) in nonallergic asthma was significantly different from controls (p = 0.038), as well as its allele distribution (p = 0.028). Using haplotype analysis, the combination frequency of the low expression of H1 homozygous and heterozygous genotype (H1/H1 + H1/H2) was significantly higher in nonallergic asthma as compared to controls (OR = 1.94, CI = 1.11–3.39, p < 0.02). The frequency of H2/H2 homozygous was higher in persistent asthma than in intermittent asthma (p = 0.008, OR = 2.625). In addition, the PDGF-AA serum level in H2/H2 homozygous haplotype was significantly lower as compared to non-H2/H2 homozygous haplotype both in asthmatic (138.1 ± 62.9 vs. 249.7 ± 97.1 ng/ml, p < 0.05) and nonallergic asthmatic children (113.8 ± 38.0 vs. 256.6 ± 58.3 ng/ml, p < 0.05). Conclusions: The developmental deficiency due to the low expression of PDGFRα may be one of the susceptible factors for nonallergic asthmatic children. There was also an autocrine effect of lower PDGF-AA and higher PDGFRα expression that might lead to airway remodeling causing the severity of asthma.

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“…The human-rodent somatic cell hybrid-mapping panel for chromosome 4 is described in Spritz et al (1994) (cell line HHW1499 was not used). Mapping was performed by PCR amplification with SOD3 primers S1/S2, S3/S4, and SG1/SG2.…”

Section: Somatic Cell Chromosome 4 Mapping Panelmentioning

confidence: 99%

“…FISH mapping was performed as described in Spritz et al (1994) using digoxigenin labeled BAC SOD-3A as hybridization probe.…”

Section: Bac Isolation and Fish Mappingmentioning

confidence: 99%

Assignment of SOD3 to human chromosome band 4p15.3→p15.1 with somatic cell and radiation hybrid mapping, linkage mapping, and fluorescent in-situ hybridization

Stern

Chapman²,

Wijsman³

et al. 2003

Cytogenet Genome Res

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A YAC Contig Spanning a Cluster of Human Type III Receptor Protein Tyrosine Kinase Genes (PDGFRA-KIT-KDR) in Chromosome Segment 4q12

Cited by 53 publications

References 0 publications

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4.

Variant in Promoter Region of Platelet-Derived Growth Factor Receptor-α (PDGFRα) Gene Is Associated with the Severity and Allergic Status of Childhood Asthma

Assignment of SOD3 to human chromosome band 4p15.3→p15.1 with somatic cell and radiation hybrid mapping, linkage mapping, and fluorescent in-situ hybridization

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