A Wolf in Sheep's clothing; Case reports and literature review of Corynebacterium striatum endocarditis

Khan, Danyal; Shadi, Mahmoud; Karam, Boutros; Munir, Abdullah B.; Lafferty, James; Glaser, Allison; Mobarakai, Neville

doi:10.1016/j.idcr.2021.e01070

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…Corynebacterium striatum is generally a common inhabitant of the human skin and upper respiratory tract. Still, it is also considered an emerging nosocomial pathogen in humans, affecting patients in opportunistic circumstances due to chronic diseases, immunosuppression, invasive medical procedures, previous antibiotic therapies and use of prosthetic devices (Khan et al 2021). A growing number of reports have demonstrated the relevance of C. striatum in the etiology of a variety of infectious processes, in both immunocompromised and immunocompetent patients: endocarditis (Mansour et Hospital outbreaks by multidrug resistant (MDR) C. striatum isolates have now been reported in many countries worldwide, including Brazil (Otsuka et al 2006 Asgin and Otlu 2020).…”

Section: Introductionmentioning

confidence: 99%

The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum

Jesus

Ramos

Rocha

et al. 2022

Funct Integr Genomics

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Corynebacterium striatum, a common constituent of the human skin microbiome, is now considered an emerging multidrug-resistant pathogen of immunocompromised and chronically ill patients. However, little is known about the molecular mechanisms in the transition from colonization to the multidrugresistant (MDR) invasive phenotype in clinical isolates. This study performed a comprehensive pangenomic analysis of C. striatum, including isolates from 'normal skin microbiome' and from MDR infections, to gain insights into genetic factors contributing to pathogenicity and multidrug resistance in this species. For this, three novel genome sequences were obtained from clinical isolates of C. striatum of patients from Brazil, and other 24 complete or draft C. striatum genomes were retrieved from GenBank, including the ATCC6940 isolate from the Human Microbiome Project. Analysis of C. striatum strains demonstrated the presence of an open pan-genome (α = 0.852803) containing 3,816 gene families, including 15 antimicrobial resistance (AMR) genes and 32 putative virulence factors. The core and accessory genomes included 1,297 and 1,307 genes, respectively. The identi ed AMR genes are primarily associated with resistance to aminoglycosides and tetracyclines. Of these, 66.6% are present in genomic islands, and four AMR genes, including aac(6')-ib7, are located in a class 1-integron. In conclusion, our data indicated that C. striatum possesses genomic characteristics favorable to the invasive phenotype, with high genomic plasticity, a robust genetic arsenal for iron acquisition, and important virulence determinants and AMR genes present in mobile genetic elements.

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Section: Introductionmentioning

confidence: 99%

The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum

Jesus

Ramos

Rocha

et al. 2022

Funct Integr Genomics

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“…In the past, C. striatum strains were described only as saprophytic microorganisms colonizing the skin and nasal mucosa of healthy individuals and unable of causing disease [ 7 ]. However, different studies have increasingly recognized C. striatum as the etiologic agent of various infections with signs and symptoms ranging from mild to severe to fatal outcomes, including bacteremia, endocarditis, meningitis, osteomyelitis, arthritis, corneal infection, and sinusitis [ 8 , 9 ]. Moreover, cases of infection of the respiratory tract, surgical wounds, skin lesions, or the eye, genital and urinary tract due to C. striatum strains have been also reported [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum

Leyton-Carcaman

Ramos

Baio

et al. 2021

IJMS

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Corynebacterium striatum, a bacterium that is part of the normal skin microbiota, is also an opportunistic pathogen. In recent years, reports of infections and in-hospital and nosocomial outbreaks caused by antimicrobial multidrug-resistant C. striatum strains have been increasing worldwide. However, there are no studies about the genomic determinants related to antimicrobial resistance in C. striatum. This review updates global information related to antimicrobial resistance found in C. striatum and highlights the essential genomic aspects in its persistence and dissemination. The resistome of C. striatum comprises chromosomal and acquired elements. Resistance to fluoroquinolones and daptomycin are due to mutations in chromosomal genes. Conversely, resistance to macrolides, tetracyclines, phenicols, beta-lactams, and aminoglycosides are associated with mobile genomic elements such as plasmids and transposons. The presence and diversity of insertion sequences suggest an essential role in the expression of antimicrobial resistance genes (ARGs) in genomic rearrangements and their potential to transfer these elements to other pathogens. The present study underlines that the resistome of C. striatum is dynamic; it is in evident expansion and could be acting as a reservoir for ARGs.

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“…C. striatum is the causative agent of various illnesses, including skin infections such as cellulitis [ 12 ], osteomyelitis [ 13 ], meningitis [ 14 ], pneumonia [ 15 ], bacteremia [ 9 , 16 , 17 , 18 , 19 , 20 ], and infective endocarditis [ 21 ]. Over the past few years, the number of reported cases has been rising due to the increase in the life expectancy of immunosuppressed patients and the improvement in microbiological techniques that are suitable for accurately identifying this microorganism [ 3 ].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, considering the role of biofilms in infective endocarditis (IE) [ 32 , 33 ], physicians should consider the possibility of infective endocarditis diagnosis in the case of bacteremia due to non-diphtheric corynebacteria. After all, IE is the most common manifestation of C. striatum [ 21 , 24 , 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium striatum Bacteremia during SARS-CoV2 Infection: Case Report, Literature Review, and Clinical Considerations

Marino

Campanella

Stracquadanio

et al. 2022

Infectious Disease Reports

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Bacterial infections, especially those in hospital settings, represent a major complication of COVID-19 patients, complicating management and worsening clinical outcomes. Corynebacterium striatum is a non-diphtheric actinobacterium that has been reported as being the causative agent of several different infections, affecting both immunocompetent and immunocompromised patients. Recently, C. striatum has been recognized as a nosocomial pathogen that is responsible for severe infection in critical patients, as well as in fragile and immunocompromised subjects. C. striatum has been described as the etiological agent of bacteremia, central line infections, and endocarditis. We report a case of a 91-year-old woman who was hospitalized due to SARS-CoV-2 infection, who developed C. striatum bacteremia and died despite antimicrobial therapy and clinical efforts. Furthermore, we discuss C. striatum diagnosis and treatment based on evidence from the scientific literature.

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A Wolf in Sheep's clothing; Case reports and literature review of Corynebacterium striatum endocarditis

Cited by 8 publications

References 11 publications

The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum

The pan-genome of the emerging multidrug-resistant pathogen Corynebacterium striatum

Treat Me Well or Will Resist: Uptake of Mobile Genetic Elements Determine the Resistome of Corynebacterium striatum

Corynebacterium striatum Bacteremia during SARS-CoV2 Infection: Case Report, Literature Review, and Clinical Considerations

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