A wireless 64-channel ECoG recording Electronic for implantable monitoring and BCI applications: WIMAGINE

Charvet, Guillaume; Foerster, M.; Chatalic, G.; Michea, A.; Porcherot, J.; Bonnet, Stéphane; Filipe, Sabine; Audebert, P.; Robinet, S.; Josselin, V.; Reverdy, Jacques; D’Errico, Raffaele; Sauter, F.; Mestais, C.; Benabid, Alim Louis

doi:10.1109/embc.2012.6346048

Cited by 15 publications

(11 citation statements)

References 10 publications

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“…Laser‐fabricated tailored electrodes (Schuettler et al, ; Henle et al, ), µECoG‐based micromachining techniques using polymer substrates (Rubehn et al, ) or on dissolvable silk (Kim et al, ) or silicon‐based foldable grids (Viventi et al, ), have broken completely new ground in BMI research, and all these techniques have to be tested and certified for human use. Therefore, there is a great demand for suitable, practical, and readily available animal models to evaluate the safety and efficiency of such new techniques to record brain activity (Gierthmuehlen et al, ; Charvet et al, ) and to broaden the knowledge of cortical (micro‐)neurophysiology for neuroscience and BMI. Ideally, such an animal model should have the following properties.…”

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confidence: 99%

Mapping of sheep sensory cortex with a novel microelectrocorticography grid

Gierthmuehlen

Wang

Gkogkidis

et al. 2014

J of Comparative Neurology

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Microelectrocorticography (µECoG) provides insights into the cortical organization with high temporal and spatial resolution desirable for better understanding of neural information processing. Here we evaluated the use of µECoG for detailed cortical recording of somatosensory evoked potentials (SEPs) in an ovine model. The approach to the cortex was planned using an MRI-based 3D model of the sheep's brain. We describe a minimally extended surgical procedure allowing placement of two different µECoG grids on the somatosensory cortex. With this small craniotomy, the frontal sinus was kept intact, thus keeping the surgical site sterile and making this approach suitable for chronic implantations. We evaluated the procedure for chronic implantation of an encapsulated µECoG recording system. During acute and chronic recordings, significant SEP responses in the triangle between the ansate, diagonal, and coronal sulcus were identified in all animals. Stimulation of the nose, upper lip, lower lip, and chin caused a somatotopic lateral-to-medial, ipsilateral response pattern. With repetitive recordings of SEPs, this somatotopic pattern was reliably recorded for up to 16 weeks. The findings of this study confirm the previously postulated ipsilateral, somatotopic organization of the sheep's sensory cortex. High gamma band activity was spatially most specific in the comparison of different frequency components of the somatosensory evoked response. This study provides a basis for further acute and chronic investigations of the sheep's sensory cortex by characterizing its exact position, its functional properties, and the surgical approach with respect to macroanatomical landmarks.

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confidence: 99%

Mapping of sheep sensory cortex with a novel microelectrocorticography grid

Gierthmuehlen

Wang

Gkogkidis

et al. 2014

J of Comparative Neurology

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“…Together with industrial partners, we are therefore currently working on the development of implantable devices for clinical use which allow for wireless transmission of intracranial multichannel signals for long-term monitoring purposes. Although similar projects have already been reported (Anderson and Harrison, 2010 ; Guillory et al, 2011 ; Hirata et al, 2011 ; Charvet et al, 2012 ), no appropriate devices are currently available for clinical use.…”

Section: Discussionmentioning

confidence: 67%

Epidural electrocorticography for monitoring of arousal in locked-in state

Martens¹,

Bensch²,

Halder³

et al. 2014

Front. Hum. Neurosci.

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Electroencephalography (EEG) often fails to assess both the level (i.e., arousal) and the content (i.e., awareness) of pathologically altered consciousness in patients without motor responsiveness. This might be related to a decline of awareness, to episodes of low arousal and disturbed sleep patterns, and/or to distorting and attenuating effects of the skull and intermediate tissue on the recorded brain signals. Novel approaches are required to overcome these limitations. We introduced epidural electrocorticography (ECoG) for monitoring of cortical physiology in a late-stage amytrophic lateral sclerosis patient in completely locked-in state (CLIS). Despite long-term application for a period of six months, no implant-related complications occurred. Recordings from the left frontal cortex were sufficient to identify three arousal states. Spectral analysis of the intrinsic oscillatory activity enabled us to extract state-dependent dominant frequencies at <4, ~7 and ~20 Hz, representing sleep-like periods, and phases of low and elevated arousal, respectively. In the absence of other biomarkers, ECoG proved to be a reliable tool for monitoring circadian rhythmicity, i.e., avoiding interference with the patient when he was sleeping and exploiting time windows of responsiveness. Moreover, the effects of interventions addressing the patient’s arousal, e.g., amantadine medication, could be evaluated objectively on the basis of physiological markers, even in the absence of behavioral parameters. Epidural ECoG constitutes a feasible trade-off between surgical risk and quality of recorded brain signals to gain information on the patient’s present level of arousal. This approach enables us to optimize the timing of interactions and medical interventions, all of which should take place when the patient is in a phase of high arousal. Furthermore, avoiding low-responsiveness periods will facilitate measures to implement alternative communication pathways involving brain-computer interfaces (BCI).

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“…B. Electronic architecture The electronic architecture of the implant was designed to be modular and evolutive [6]. For this first version, we decided not to embed all the functionalities required for an ECoG recording implant into an application specific circuit (ASIC) but rather to use as much of the shelf components as possible.…”

Section: The Wimagine ® Implant Architecturementioning

confidence: 99%

WIMAGINE<sup>®</sup>: 64-channel ECoG recording implant for human applications

Charvet

Sauter-Starace

Foerster

et al. 2013

2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)

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A wireless 64-channel ElectroCorticoGram (ECoG) recording implant named WIMAGINE(®) has been designed for clinical applications. This active implantable medical device is able to record ECoG on 64 electrodes with selectable gain and sampling frequency, with less than 0.7 µVRMS input referred noise in the [0.5 Hz - 300 Hz] band. It is powered remotely through an inductive link at 13.56 MHz, communicates wirelessly on the MICS band at 402-405 MHz with a custom designed base station connected to a PC and complies with the regulations applicable to class III AIMD. The design of the housing and the antenna have been optimized to ease the surgery and to take into account all the requirements of a clinical trial in particular patient safety and comfort. The main features of this WIMAGINE(®) implantable device and its architecture will be presented, as well as its performances and in vivo validations.

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A wireless 64-channel ECoG recording Electronic for implantable monitoring and BCI applications: WIMAGINE

Cited by 15 publications

References 10 publications

Mapping of sheep sensory cortex with a novel microelectrocorticography grid

Mapping of sheep sensory cortex with a novel microelectrocorticography grid

Epidural electrocorticography for monitoring of arousal in locked-in state

WIMAGINE<sup>®</sup>: 64-channel ECoG recording implant for human applications

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A wireless 64-channel ECoG recording Electronic for implantable monitoring and BCI applications: WIMAGINE

Cited by 15 publications

References 10 publications

Mapping of sheep sensory cortex with a novel microelectrocorticography grid

Mapping of sheep sensory cortex with a novel microelectrocorticography grid

Epidural electrocorticography for monitoring of arousal in locked-in state

WIMAGINE<sup>&#x00AE;</sup>: 64-channel ECoG recording implant for human applications

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Product

Resources

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WIMAGINE<sup>®</sup>: 64-channel ECoG recording implant for human applications