A winning strategy to improve the anticancer properties of Cisplatin and Quercetin based on the nanoemulsions formulation

Ceramella, Jessica; Groo, Anne-Claire; Iacopetta, Domenico; Séguy, Line; Mariconda, Annaluisa; Puoci, Francesco; Saturnino, Carmela; Leroy, Fanny; Since, Marc; Longo, Pasquale; Malzert‐Fréon, Aurélie; Sinicropi, Maria Stefania

doi:10.1016/j.jddst.2021.102907

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…The in vitro antitumor activities of all the target compounds were determined by using the MTT (Sigma) assay, as already described ( Sinicropi et al, 2018 ). Cells were exposed to the different extracts dissolved in DMSO at different concentrations (50, 100, 200, 400 and 500 µg/mL) for 72 h. Then MTT was added as already reported ( Ceramella et al, 2021 ). The IC 50 values were obtained by using GraphPad Prism 9 (GraphPad Software, La Jolla, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Exploring the anticancer and antioxidant properties of Vicia faba L. pods extracts, a promising source of nutraceuticals

Ceramella

Torre

Luca

et al. 2022

PeerJ

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Background Pulse crops are considered the major sources of proteins, dietary fiber, micronutrients, and bioactive phytochemicals. Among the numerous pulse crops, broad beans (Vicia faba L.) have received particular attention due to their nutraceutical, functional and economic importance. Our attention was mainly focused on the broad bean pods (VFs), which are the primary by-product of the domestic and industrial processing of broad beans and an attractive source of valuable ingredients. Methods In order to investigate the VFs properties, the flours from broad beans of three different harvest periods were extracted with acetone, methanol and 70% aqueous ethanol and the dried extracts were analyzed, qualitatively and quantitatively, and tested for their antioxidant through DPPH and ABTS assay and anticancer activities using the MTT assay and immunofluorescence analysis. Results The VF extracts demonstrated a good in vitro radical scavenging activity from the first stage of collection of all the V. faba L. extracts. Additionally, the extracts were tested for their cytotoxicity against a panel of cancer and normal cells and the outcomes indicated the ethanol extract as the most active against the melanoma cell line Sk-Mel-28, without affecting the viability of the normal cells. Finally, we found out that the ethanol extract interfered with the microtubules organization, leading to the cancer cells death by apoptosis.

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Section: Methodsmentioning

confidence: 99%

Exploring the anticancer and antioxidant properties of Vicia faba L. pods extracts, a promising source of nutraceuticals

Ceramella

Torre

Luca

et al. 2022

PeerJ

Self Cite

View full text Add to dashboard Cite

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“…Nanoemulsion formulations have also improved the anticancer properties of both Cisplatin and Quercetin tested against breast cancer MDA-MB-231 and renal HEK-293 cells. Results also showed the synergistic effect of Quercetin/Cisplatin against MDA-MB-231 [ 87 ].…”

Section: Antioxidant-loaded Delivery Systems As Emerging Therapeutic ...mentioning

confidence: 99%

Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

et al. 2023

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Cancer is one of the major diseases leading to death worldwide, and the fight against the disease is still challenging. Cancer diseases are usually associated with increased oxidative stress and the accumulation of reactive oxygen and nitrogen species as a result of metabolic alterations or signaling aberrations. While numerous antioxidants exhibit potential therapeutic properties, their clinical efficiency against cancer is limited and even unproven. Conventional anticancer antioxidants and drugs have, among others, the great disadvantage of low bioavailability, poor targeting efficiency, and serious side effects, constraining their use in the fight against diseases. Here, we review the rationale for and recent advances in potential delivery systems that could eventually be employed in clinical research on antioxidant therapy in cancer. We also review some of the various strategies aimed at enhancing the solubility of poorly water-soluble active drugs, including engineered delivery systems such as lipid-based, polymeric, and inorganic formulations. The use of cyclodextrins, micro- and nanoemulsions, and thermosensitive smart liposomes as useful systems for the delivery and release of poorly aqueous-soluble drugs, improving their bioactivity and stability, is also addressed. We also provide some details on their formulation processes and their use in a variety of medical applications. Finally, we briefly cover a case study specifically focused on the use of delivery systems to minimize oral cancer and associated dental problems.

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“…Employing NEs containing the above-mentioned substances lessened the principal cytotoxic activity of cisplatin on HEK-293 cells significantly. In addition, the antioxidant properties of encapsulated quercetin were enhanced [ 108 ].…”

Section: Lipid-based Carrier Systemsmentioning

confidence: 99%

Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles

et al. 2023

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Herbal chemicals with a long history in medicine have attracted a lot of attention. Flavonolignans and flavonoids are considered as two classes of the above-mentioned compounds with different functional groups which exhibit several therapeutic capabilities such as antimicrobial, anti-inflammatory, antioxidant, antidiabetic, and anticancer activities. Based on the studies, high hydrophobic properties of the aforementioned compounds limit their bioavailability inside the human body and restrict their wide application. Nanoscale formulations such as solid lipid nanoparticles, liposomes, and other types of lipid-based delivery systems have been introduced to overcome the above-mentioned challenges. This approach allows the aforementioned hydrophobic therapeutic compounds to be encapsulated between hydrophobic structures, resulting in improving their bioavailability. The above-mentioned enhanced delivery system improves delivery to the targeted sites and reduces the daily required dosage. Lowering the required daily dose improves the performance of the drug by diminishing its side effects on non-targeted tissues. The present study aims to highlight the recent improvements in implementing lipid-based nanocarriers to deliver flavonolignans and flavonoids.

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A winning strategy to improve the anticancer properties of Cisplatin and Quercetin based on the nanoemulsions formulation

Cited by 10 publications

References 32 publications

Exploring the anticancer and antioxidant properties of Vicia faba L. pods extracts, a promising source of nutraceuticals

Exploring the anticancer and antioxidant properties of Vicia faba L. pods extracts, a promising source of nutraceuticals

Innovative Delivery and Release Systems for Antioxidants and Other Active Substances in the Treatment of Cancer

Lipid-Based Delivery Systems for Flavonoids and Flavonolignans: Liposomes, Nanoemulsions, and Solid Lipid Nanoparticles

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