A Window into Mammalian Basement Membrane Development: Insights from themTurq2-Col4a1Mouse Model
Rebecca A. Jones,
Brandon Trejo,
Parijat Sil
et al.
Abstract:Basement membranes (BMs) are specialized sheets of extracellular matrix that underlie epithelial and endothelial tissues. BMs regulate traffic of cells and molecules between compartments, and participate in signaling, cell migration and organogenesis. The dynamics of mammalian BMs, however, are poorly understood, largely due to a lack of models in which core BM components are endogenously labelled. Here, we describe themTurquoise2-Col4a1mouse, in which we fluorescently tag collagen IV, the main component of BM… Show more
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