A wider role for congenital cytomegalovirus infection in sensorineural hearing loss

Barbi, Maria; Binda, Sandro; Caroppo, Simona; Ambrosetti, Umberto; Corbetta, Carlo; Sergi, P.

doi:10.1097/00006454-200301000-00012

Cited by 155 publications

(125 citation statements)

References 11 publications

Supporting

Mentioning

109

Contrasting

Unclassified

Order By: Relevance

“…In 13 children with sensorineural hearing loss (54% of the study group), the etiology remains undetermined. A recent Italian study, utilizing PCR analysis of newborn spots for CMV DNA, suggests that intrauterine CMV infection accounts for as many as 30% of children with sensorineural hearing loss [Barbi et al, 2003]. In an effort to thoroughly examine this population for all components of hearing loss, we are collaborating on a CDC-funded study of CMV infection to determine its contribution to newborn hearing loss in Utah.…”

Section: Discussionmentioning

confidence: 99%

Methodology of a multistate study of congenital hearing loss: Preliminary data from Utah newborn screening

Dent

Kenneson

Palumbos

et al. 2004

American J of Med Genetics Pt C

View full text Add to dashboard Cite

A multistate Centers for Disease Control and Prevention (CDC) study was designed to investigate the etiology of congenital hearing loss in infants ascertained through state-mandated hearing screening or early hearing loss detection and intervention (EHDI) programs. At least 50% of permanent childhood-onset hearing loss is due to genetic causes, and approximately 20% of all infants with congenital hearing loss have mutations in the GJB2 gene. Another 1% of childhood hearing loss is due to mitochondrial DNA (mtDNA) mutations. The specific aims of this study are to 1) classify the etiology of congenital hearing loss in infants by doing prospective genetic evaluations of all newborns with permanent hearing loss from defined geographic areas, 2) determine the frequency of mutations in GJB2 and two common mitochondrial mutations in these populations, and 3) establish a model infrastructure linking genetic services to statewide EHDI programs. As of April 2003, Utah is the only center evaluating patients. Study subjects identified through the Utah Department of Health EHDI program are contacted by letter and offered a comprehensive medical genetics evaluation with DNA testing for GJB2 and mitochondrial mutations A1555G and A7445G. To date, 25 probands and their immediate family members have been evaluated. We have identified 20 cases with nonsyndromic hearing loss (7 multiplex and 13 simplex), 4 with syndromic hearing loss, and 1 with presumed cytomegalovirus (CMV)-induced hearing loss. Six of 19 (32%) nonsyndromic cases with sensorineural hearing loss have mutations of one or both alleles of the GJB2 gene, and 21% are homozygous or compound heterozygotes for the 35delG mutation. No A1555G or A7445G mtDNA mutations have been found. Data reported to date include only children born in Utah, but EHDI programs in Hawaii, Rhode Island, and designated areas of Georgia have begun enrolling children in what is now a multistate collaborative study. This is the first comprehensive investigation to determine the etiology of hearing loss from populations ascertained through EHDI programs. The results of this study will facilitate the incorporation of genetic services into EHDI programs. ß

show abstract

Section: Discussionmentioning

confidence: 99%

Methodology of a multistate study of congenital hearing loss: Preliminary data from Utah newborn screening

Dent

Kenneson

Palumbos

et al. 2004

American J of Med Genetics Pt C

View full text Add to dashboard Cite

show abstract

“…[42][43][44][45] However, it is assumed that the importance of asymptomatic cCMV as a cause of hearing loss may be higher than currently believed. 3,46,47 This systematic review provides an overview of the prevalence of cCMV-related hearing loss based on the literature of the past 50 years and aims at better defining the nature of cCMV-associated hearing loss and the importance of cCMV among patients with childhood hearing loss.…”

mentioning

confidence: 99%

Hearing Loss and Congenital CMV Infection: A Systematic Review

Goderis¹,

Leenheer²,

et al. 2014

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance of cCMV infection in hearing-impaired children. METHODS:Two reviewers independently used Medline and manual searches of references from eligible studies and review articles to select cohort studies on children with cCMV infection with audiological follow-up and extracted data on population characteristics and hearing outcomes. RESULTS:Thirty-seven studies were included: 10 population-based natural history studies, 14 longitudinal cohort studies, and 13 retrospective studies. The prevalence of cCMV in developed countries is 0.58% (95% confidence interval, 0.41-0.79). Among these newborns 12.6% (95% confidence interval, 10.2-16.5) will experience hearing loss: 1 out of 3 symptomatic children and 1 out of 10 asymptomatic children. Among symptomatic children, the majority have bilateral loss; among asymptomatic children, unilateral loss predominates. In both groups the hearing loss is mainly severe to profound. Hearing loss can have a delayed onset, and it is unstable, with fluctuations and progression. Among hearing-impaired children, cCMV is the causative agent in 10% to 20%. Despite strict selection criteria, some heterogeneity was found between selected studies.CONCLUSIONS: This systematic review underscores the importance of cCMV as a cause of sensorineural hearing loss in childhood. Pediatrics 2014;134:972-982

show abstract

“…This test has also been used to evaluate the prevalence of congenital CMV infection in children with cortical development disorders (such as pachigiria and leucodystrophy of unknown origin) (52). The same test revealed that 20-30% of all cases of infantile deafness were due to congenital CMV infection (53,54).…”

Section: (Asd) Are Neurodevelopmental Disorders Without a Definitive mentioning

confidence: 99%

Prevalence of Congenital Cytomegalovirus Infection Assessed Through Viral Genome Detection in Dried Blood Spots in Children with Autism Spectrum Disorders

Gentile

Zappulo

Riccio

et al. 2017

Self Cite

View full text Add to dashboard Cite

A wider role for congenital cytomegalovirus infection in sensorineural hearing loss

Cited by 155 publications

References 11 publications

Methodology of a multistate study of congenital hearing loss: Preliminary data from Utah newborn screening

Methodology of a multistate study of congenital hearing loss: Preliminary data from Utah newborn screening

Hearing Loss and Congenital CMV Infection: A Systematic Review

Prevalence of Congenital Cytomegalovirus Infection Assessed Through Viral Genome Detection in Dried Blood Spots in Children with Autism Spectrum Disorders

Contact Info

Product

Resources

About