A wide range of Deep Brain Stimulation of the nucleus accumbens shell time independently reduces the extinction period and prevents the reinstatement of methamphetamine-seeking behavior in rats

Eskandari, Kiarash; Fattahi, Mojdeh; Riahi, Esmail; Khosrowabadi, Reza; Haghparast, Abbas

doi:10.1016/j.lfs.2023.121503

Cited by 12 publications

(1 citation statement)

References 58 publications

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“…Further studies using fMRI also found that high-frequency DBS of the DRN leads to increased FC between the DRN and IL. Moreover, studies have also shown that the NAc shell can be an effective target for addiction treatment, with high-frequency DBS of the NAc shell proving effective in inhibiting drug-primed seeking behavior for cocaine and methamphetamine [ 35 , 36 ]. Meanwhile, we also observed that high-frequency DBS of the DRN led to activation in both the OFC and VTA.…”

Section: Discussionmentioning

confidence: 99%

High frequency deep brain stimulation of the dorsal raphe nucleus prevents methamphetamine priming-induced reinstatement of drug seeking in rats

Zhang,

Meng,

Huang

et al. 2024

Transl Psychiatry

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Drug addiction represents a multifaceted and recurrent brain disorder that possesses the capability to create persistent and ineradicable pathological memory. Deep brain stimulation (DBS) has shown a therapeutic potential for neuropsychological disorders, while the precise stimulation targets and therapeutic parameters for addiction remain deficient. Among the crucial brain regions implicated in drug addiction, the dorsal raphe nucleus (DRN) has been found to exert an essential role in the manifestation of addiction memory. Thus, we investigated the effects of DRN DBS in the treatment of addiction and whether it might produce side effects by a series of behavioral assessments, including methamphetamine priming-induced reinstatement of drug seeking behaviors, food-induced conditioned place preference (CPP), open field test and elevated plus-maze test, and examined brain activity and connectivity after DBS of DRN. We found that high-frequency DBS of the DRN significantly lowered the CPP scores and the number of active-nosepokes in the methamphetamine-primed CPP test and the self-administration model. Moreover, both high-frequency and sham DBS group rats were able to establish significant food-induced place preference, and no significant difference was observed in the open field test and in the elevated plus-maze test between the two groups. Immunofluorescence staining and functional magnetic resonance imaging revealed that high-frequency DBS of the DRN could alter the activity and functional connectivity of brain regions related to addiction. These results indicate that high-frequency DBS of the DRN effectively inhibits methamphetamine priming-induced relapse and seeking behaviors in rats and provides a new target for the treatment of drug addiction.

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Section: Discussionmentioning

confidence: 99%