A whole-exome sequencing study of patent foramen ovale: investigating genetic variants and their association with cardiovascular disorders
Xinyi Li,
Lingling Xie,
Jin Dai
et al.
Abstract:BackgroundPatent foramen ovale (PFO) has a genetic predisposition and is closely associated with cryptogenic stroke (CS), migraine, decompression sickness, and hypoxemia. Identifying PFO-related mutant genes through whole-exome sequencing (WES) can help in the early recognition of cardiovascular genetic risk factors, guide timely clinical intervention, and reduce the occurrence of cardiovascular events.MethodsWe analyzed mutant genes from ClinVar and OMIM databases. WES was performed on 25 PFO patients from Zh… Show more
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