A whole body autoradiographic study on the distribution of 14C-labelled Di-(2-ethylhexyl)phthalate in mice

Lindgren, Arne; Lindquist, Nils Gunnar; Lydén, Annika; Olsson, Thomas; Ullberg, Sven

doi:10.1016/0300-483x(82)90094-4

Cited by 19 publications

(9 citation statements)

References 22 publications

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“…The radioactivity was excreted in urine and feces mainly in the first 24 h and completely within 3-5 days. Lindgren and coworkers [147] described a similar study in pregnant and nonpregnant female mice. Pretreatment with DEHP, sodium phenobarbital or 3-methylchoanthrene caused a relative increase in the activity in brown fat.…”

Section: Metabolism and Biodegradationmentioning

confidence: 88%

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Phthalic Acid Esters

Giam

Atlas

Powers

et al. 1984

The Handbook of Environmental Chemistry

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Section: Metabolism and Biodegradationmentioning

confidence: 88%

“…There was no evidence of tissue storage. Lindgren and coworkers [147] described a similar study on the distribution of 14 C-DEHP in pregnant and nonpregnant female mice. High activity was observed initially in brown fat, liver, gall bladder, intestinal contents, kidney, and urinary bladder.…”

Section: Assessment Of Modelling Parametersmentioning

confidence: 91%

Phthalic Acid Esters

Giam

Atlas

Powers

et al. 1984

The Handbook of Environmental Chemistry

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“…Once they enter the body, diester phthalates are rapidly hydrolyzed into monoester forms [ 4 , 9 ]. These biomarkers have been found in the liver, kidney and testis of rats, marmosets and mice [ 52 , 53 ]; in the fat and muscle tissues of sheep [ 20 ], in bovine fat tissue [ 19 ]; and in the blood of humans [ 10 ], mice [ 54 ], rats and marmosets [ 52 ]. In addition, DEHP has been detected in female sheep plasma 29 days after injection [ 55 ].…”

Section: Discussionmentioning

confidence: 99%

Carryover Effects of Acute DEHP Exposure on Ovarian Function and Oocyte Developmental Competence in Lactating Cows

et al. 2015

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We examined acute exposure of Holstein cows to di(2-ethylhexyl) phthalate (DEHP) and its carryover effects on ovarian function and oocyte developmental competence. Synchronized cows were tube-fed with water or 100 mg/kg DEHP per day for 3 days. Blood, urine and milk samples were collected before, during and after DEHP exposure to examine its clearance pattern. Ovarian follicular dynamics was monitored through an entire estrous cycle by ultrasonographic scanning. Follicular fluids were aspirated from the preovulatory follicles on days 0 and 29 of the experiment and analyzed for phthalate metabolites and estradiol concentration. The aspirated follicular fluid was used as maturation medium for in-vitro embryo production. Findings revealed that DEHP impairs the pattern of follicular development, with a prominent effect on dominant follicles. The diameter and growth rate of the first- and second-wave dominant follicles were lower (P < 0.05) in the DEHP-treated group. Estradiol concentration in the follicular fluid was lower in the DEHP-treated group than in controls, and associated with a higher number of follicular pathologies (follicle diameter >25 mm). The pattern of growth and regression of the corpus luteum differed between groups, with a lower volume in the DEHP-treated group (P < 0.05). The follicular fluid aspirated from the DEHP-treated group, but not the controls, contained 23 nM mono(2-ethylhexyl) phthalate. Culturing of cumulus oocyte complexes in the follicular fluid aspirated from DEHP-treated cows reduced the proportion of oocytes progressing to the MII stage, and the proportions of 2- to 4-cell-stage embryos (P < 0.04) and 7-day blastocysts (P < 0.06). The results describe the risk associated with acute exposure to DEHP and its deleterious carryover effects on ovarian function, nuclear maturation and oocyte developmental competence.

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“…DEHP and its metabolites may be secreted into the milk of lactating rats (Dostal et al 1987, Parmar et al 1985 and also pass into human milk (Bruns-Weller and Pfjordt 2000, , Gruber et al 1998, Mortensen et al 2005, Zhu et al 2006. In rodents 14 C-DEHP has found to cross the placenta barrier and distribute into foetal tissues (Lindgren et al 1982, Singh et al 1975, Srivastava et al 1989). The monoester MEHP was found in rat and human amniotic fluid ).…”

Section: Metabolism Of Dehp In Humansmentioning

confidence: 99%

Plasticizer concentration in cord blood cryopreserved with DMSO

Yamaguchi

Takanashi

Ito

et al. 2013

Bone Marrow Transplant

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The Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) has evaluated the exposure to DEHP for the general population and patients during medical procedures. In many cases the exposure is significant and exceeds the toxic doses observed in animal studies. There is limited evidence indicating a relation between DEHP exposures and certain effects in humans. However, it is recognised that especially the potentially high exposure during medical treatments raise a concern, even in the absence of clinical or epidemiological evidence, for harmful effects in humans. For certain uses of DEHP alternative plasticizers for PVC are available. The Committee got access to toxicity data for eight possible alternative plasticizers and compared their toxicity with that of DEHP. In respect to reproductive toxicity in animal studies DEHP induces more severe effects compared with some of the alternatives. A risk assessment of these available alternative plasticizers could not be performed due to a lack of exposure data from medical devices. Each alternative to DEHP, however, must also be evaluated with regard to their functionality in respect to medical devices. The risk and benefits of using alternative plasticizers should be evaluated case by case.

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A whole body autoradiographic study on the distribution of 14C-labelled Di-(2-ethylhexyl)phthalate in mice

Cited by 19 publications

References 22 publications

Phthalic Acid Esters

Phthalic Acid Esters

Carryover Effects of Acute DEHP Exposure on Ovarian Function and Oocyte Developmental Competence in Lactating Cows

Plasticizer concentration in cord blood cryopreserved with DMSO

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