A wet adhesion strategy <i>via</i> synergistic cation–π and hydrogen bonding interactions of antifouling zwitterions and mussel-inspired binding moieties

Cotton gauze is a widely used topical hemostatic material for bleeding control, but its high blood absorption capacity tends to cause extra blood loss. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Here, we develop an efficient hemostatic cotton gauze whose surface is slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in animal injuries is superior to standard cotton gauze and Combat GauzeTM. Its biosafety is similar to cotton gauze and rebleeding hardly occurs when the gauze is removed. Here, we show its hemostatic capability is attributable to the rapid formation of big and thick primary erythrocyte clots, due to its effective controlling of blood movement through blocking effect from tissue adhesion by catechol, blood wicking in cotton, and the hydrophobic effect from long alkyl chains.

show abstract

“…13 ). This further confirms that catechol group plays an essential role in the wet tissue adhesion 26 – 28 .…”

Section: Resultssupporting

confidence: 75%

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Zhou

Gao

et al. 2022

Nat Commun

View full text Add to dashboard Cite

show abstract

“…We employed here a total of six molecules as SAMs featuring noncharged ones, e.g., mercaptohexanol (MCH) and OEG; monocharged ones, e.g., AC and SP; zwitterionic ones, e.g., AP and PC (Figure , Table S1). They all contain hydrophilic moieties as their head groups, among which MCH is a traditional SAM employed in E-AB sensors and the other five molecules were prepared according to previous literature studies. − We first characterized the surface properties of these SAMs using contact angle and confocal microscopy and then investigated the effect of these SAMs varying in end-group structures on the performance of E-AB sensors, when they are deployed in urine, sweat, and blood samples, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Five custom synthesized monolayers, including noncharged oligoethylene glycol (OEG); monocharged ones, e.g., trimethylammonium chloride (AC) and sulfopropylmethacrylate potassium (SP); and zwitterionic ones, e.g., (dimethylammonio)propane sulfonate (AP), were synthesized according to previous literature studies. − Tris(2-carboethyl)-phosphine hydrochloride (TCEP) and bovine serum albumin (BSA) were purchased from Sigma-Aldrich; doxorubicin (DOX) and 6-mercapto-1-hexanol (MCH) were purchased from Aladdin; all were used as received. Microcloth (2 and 7/8″) and 1 μm and 0.05 μm alumina powder were obtained from CH Instruments Ins.…”

Section: Methodsmentioning

confidence: 99%

Exploring End-Group Effect of Alkanethiol Self-Assembled Monolayers on Electrochemical Aptamer-Based Sensors in Biological Fluids

Wang

Zhang

et al. 2021

Anal. Chem.

View full text Add to dashboard Cite

The continuous, real-time monitoring of specific analytes in situ in biological fluids would provide personalized, high-precision pharmacokinetic information for the goal of precision medicine. Due to their conformationally linked signaling mechanism, electrochemical aptamer-based (E-AB) sensors are promising candidates for accurate measurements in such complex media. They suffer, however, from severe baseline drift when interrogated continuously and in real-time manner. In response, here, we investigate a couple of self-assembled monolayers in the application of E-AB sensors, achieving the improvement of their baseline stability and simultaneous modulation of sensor performance, e.g., target affinity and specificity.

show abstract

“…This further confirms that catechol group plays an essential role in the wet tissue adhesion. [26][27][28] In order to demonstrate the importance of tissue adhesion of catechol to high hemostatic efficiency, the catechol group on USO-g-gauze is transformed to lower its tissue adhesiveness. Hence, USOFe-g-gauze and USOQu-g-gauze were fabricated.…”

Section: Hemostatic Mechanism Of the Highly Efficient Uso-g-gauzementioning

confidence: 99%

A super-efficient and biosafe hemostatic cotton gauze with controlled balance of hydrophilicity/hydrophobicity and tissue adhesiveness

Zhou

Gao

et al. 2021

Preprint

View full text Add to dashboard Cite

Cotton gauze is a widely used topical hemostatic material for bleeding control in military and civil accidents and surgical operations, but its high blood absorption capacity tends to cause extra blood loss of the wounded person, which may increase the risk of shock and death. Therefore, development of rapid hemostatic cotton gauze with less blood loss is of great significance. Herein, we prepared a super-efficient hemostatic cotton gauze whose surface was slightly modified with a catechol compound which features a flexible long hydrophobic alkyl chain terminated with a catechol group. Its hemostatic performance in rat and pig injury models was far superior to standard cotton gauze and Combat GauzeTM. The latter is a well-known commercial gauze for controlling massive hemorrhaging. Additionally, after stoppage of bleeding, the wound sites hardly re-bleed upon the gauze was peeled off. Histological analysis proved that the novel cotton gauze well kept the biosafety of cotton gauze. Interestingly, a similar impressive hemostatic performance was also achieved for chitosan nonwoven gauze modified with the same procedure. Density functional theory calculation and instrumental measurements demonstrate that their extraordinary hemostatic capability is attributable to the highly efficient formation of big and thick primary blood clot made of massive aggregated erythrocytes, due to gauze’s effective controlling of blood movement through its blocking effect from tissue adhesion by catechol, platelet activation by cotton fiber, blood absorption by cotton, and hydrophobic effect from long alkyl chain. The methodology and hemostatic mechanisms presented in this work may open a new avenue for developing highly efficient hemostatic gauzes.

show abstract

A wet adhesion strategy via synergistic cation–π and hydrogen bonding interactions of antifouling zwitterions and mussel-inspired binding moieties

Abstract: An orientation-mediated zwitterion–Dopa binding mechanism is established as a promising wet adhesion strategy to design zwitterion–Dopa-mediated adhesive materials.

Cited by 72 publications

References 59 publications

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Efficient, biosafe and tissue adhesive hemostatic cotton gauze with controlled balance of hydrophilicity and hydrophobicity

Exploring End-Group Effect of Alkanethiol Self-Assembled Monolayers on Electrochemical Aptamer-Based Sensors in Biological Fluids

A super-efficient and biosafe hemostatic cotton gauze with controlled balance of hydrophilicity/hydrophobicity and tissue adhesiveness

Contact Info

Product

Resources

About