A Well-Circumscribed Border with Peripheral Doppler Signal in Sonographic Image Distinguishes Epithelioid Trophoblastic Tumor from Other Gestational Trophoblastic Neoplasms

Abstract

As epithelioid trophoblastic tumor (ETT) shares similar clinical features with other gestational trophoblastic neoplasms (GTNs), it is likely to be clinically misdiagnosed and subsequently treated in an improper way. This study aimed to identify the sonographic features of ETT that are distinct from other GTNs, including placental site trophoblastic tumor (PSTT) and invasive mole/choriocarcinoma (IM/CC). Here, we retrospectively analyzed ultrasound images of 12 patients with ETT in comparison with those of 21 patients with PSTT and 24 patients with IM/CC. The results showed that maximal diameter and hemodynamic parameters were not significantly different among ETT, PSTT and IM/CC (P>0.05). However, a well-circumscribed border with hypoechogenic halo was identified in the gray-scale sonogram in all 12 cases of ETT, while only in 1 out of 21 cases of PSTT and 1 out of 16 cases of IM/CC (P<0.001 for ETT vs. PSTT or IM/CC). Moreover, a peripheral pattern of Doppler signals was observed in 11 out of 12 ETT lesions, showing relatively more Doppler signal spots around the tumor border than within the boundary, while a non-peripheral pattern of Doppler signals in all 21 PSTT cases and 14 out of 16 IM/CC cases: with minimal, moderate or remarkable signal spots within the tumor, but not along the tumor (P<0.001 for ETT vs. PSTT or IM/CC). These distinct sonographic features of ETT correlated with histopathologic observations, such as expansive growth pattern and vascular morphology. Thus, we draw the conclusions that the well-circumscribed border with peripheral Doppler signal may serve as a reliable sonographic feature to discriminate ETT from other types of GTNs. With further validation in a larger patient set in our ongoing multi-center study, this finding will be potentially developed into a non-invasive pre-operative GTN subtyping method for ETT.

Epithelioid trophoblastic tumor of the uterus: A case report with radiologic–pathologic correlation

“…10 Qin et al reported that Doppler ultrasound signals were observed only in the peripheral area of the tumor in 11 of 12 ETTs. 11 This ultrasound finding is consistent with the DCE-MR finding in our case. We attribute these findings to massive necrosis in the center of the tumor.…”

“…This correlation can serve as an important clue for the differentiation of ETT from other GTDs because most GTDs appear as hypervascular tumors on DCE‐MR images . Qin et al reported that Doppler ultrasound signals were observed only in the peripheral area of the tumor in 11 of 12 ETTs . This ultrasound finding is consistent with the DCE‐MR finding in our case.…”

Sonographic image of cervix epithelioid trophoblastic tumor coexisting with mucinous adenocarcinoma in a postmenopausal woman

“…Because of nonpenetrated by tumor cells, the intratumoral vessels of ETT are too small to be detected in Color Doppler image, or be just showed as low blood signals. [ 13 ] Same with Qin and colleagues’ finding, we identified a Doppler signal spotted around the tumor instead of within the tumor. This was distinct from IM and CC.…”

Gestational Trophoblastic Disease: Clinical and Imaging Features

“…A specific US appearance that may aid in differentiating ETT from other types of GTN has been described as a well-circumscribed mass with sharp borders and a peripheral halo of low echogenicity at gray-scale US and peripheral increased vascularity at color Doppler US (41,42). However, this pattern is not characteristic of all cases of ETT, and lesions may demonstrate decreased vascularity (Fig 11) (42).…”