A Web Platform for data acquisition and analysis for Alzheimer's disease

Lizarraga, Gabriel; Cabrerizo, Mercedes; Duara, Ranjan; Rojas, Niovi; Adjouadi, Malek; Loewenstein, David

doi:10.1109/secon.2016.7506730

Cited by 10 publications

(2 citation statements)

References 16 publications

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“…The PET/CT scans, including the outline of the skull were co-registered linearly (i.e., trilinear interpolation) with 12 degrees of freedom, onto the volumetric MRI scan using a T1-weighted MP-RAGE image ( Lizarraga et al, 2016 ). Region-of-interest (ROI) boundaries were defined manually using the structural MRI for anatomical reference, and criteria that have been proven to provide highly reproducible outcomes ( Desikan et al, 2006 ).…”

Section: Methodsmentioning

confidence: 99%

Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia

Curiel Cid,

Crocco,

Duara

et al. 2024

Front. Aging Neurosci.

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IntroductionThis study investigated the role of proactive semantic interference (frPSI) in predicting the progression of amnestic Mild Cognitive Impairment (aMCI) to dementia, taking into account various cognitive and biological factors.MethodsThe research involved 89 older adults with aMCI who underwent baseline assessments, including amyloid PET and MRI scans, and were followed longitudinally over a period ranging from 12 to 55 months (average 26.05 months).ResultsThe findings revealed that more than 30% of the participants diagnosed with aMCI progressed to dementia during the observation period. Using Cox Proportional Hazards modeling and adjusting for demographic factors, global cognitive function, hippocampal volume, and amyloid positivity, two distinct aspects of frPSI were identified as significant predictors of a faster decline to dementia. These aspects were fewer correct responses on a frPSI trial and a higher number of semantic intrusion errors on the same trial, with 29.5% and 31.6 % increases in the likelihood of more rapid progression to dementia, respectively.DiscussionThese findings after adjustment for demographic and biological markers of Alzheimer’s Disease, suggest that assessing frPSI may offer valuable insights into the risk of dementia progression in individuals with aMCI.

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Section: Methodsmentioning

confidence: 99%

Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia

Curiel Cid,

Crocco,

Duara

et al. 2024

Front. Aging Neurosci.

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show abstract

“…The PET/CT scans, including the outline of the skull, co-registered linearly (i.e. trilinear interpolation) with 12 degrees of freedom, onto the volumetric MRI scan using a T1-weighted (MP-RAGE) (Lizarraga et al, 2016;Smith et al, 2004) region-of-interest (ROI) boundaries were defined manually using the structural MRI for anatomical reference, and criteria that have been proven to provide highly reproducible outcomes (Desikan et al, 2006). This registration process ensured that the florbetaben PET/CT image had the same accurate segmentation and parcellation as in the MRI scan.…”

Section: Loewenstein-acevedo Scales For Semantic Interference and Lea...mentioning

confidence: 99%

Semantic intrusion errors as a function of age, amyloid, and volumetric loss: a confirmatory path analysis

Zheng

Curiel

Duara

et al. 2021

Int. Psychogeriatr.

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Objective: To examine the direct and indirect effects of age, APOE ϵ4 genotype, amyloid positivity, and volumetric reductions in AD-prone brain regions as it relates to semantic intrusion errors reflecting proactive semantic interference (PSI) and the failure to recover from proactive semantic interference (frPSI) on the Loewenstein-Acevedo Scales of Semantic Interference and Learning (LASSI-L), a cognitive stress test that has been consistently more predictive of preclinical and prodromal Alzheimer’s disease (AD) than traditional list-learning tests. Design: Cross-sectional study. Setting: 1Florida Alzheimer’s Disease Research Center baseline study. Participants: Two-hundred and twelve participants with Mini-Mental State Examination (MMSE) score above 16 and a broad array of cognitive diagnoses ranging from cognitively normal (CN) to dementia, of whom 58% were female, mean age of 72.1 (SD 7.9). Measures: Participants underwent extensive clinical and neuropsychological evaluations, MR and amyloid Positron Emission Tomography/Computer/Computer Tomography (PET/CT) imaging, and analyses of APOE ϵ4 genotype. Confirmatory path analyses were conducted in the structural equation modeling framework that estimated multiple equations simultaneously while controlling for important covariates such as sex, education, language of evaluation, and global cognitive impairment. Results: Both amyloid positivity and decreased brain volumes in AD-prone regions were directly related to LASSI-L Cued B1 and Cued B2 intrusions (sensitive to PSI and frPSI effects) even after controlling for covariates. APOE ϵ4 status did not evidence direct effects on these LASSI-L cognitive markers, but rather exerted their effects on amyloid positivity, which in turn related to PSI and frPSI. Similarly, age did not have a direct relationship with LASSI-L scores, but exerted its effects indirectly through amyloid positivity and volumes of AD-prone brain regions. Conclusions: Our study provides insight into the relationships among age, APOE ϵ4, amyloid, and brain volumetric reductions as it relates to semantic intrusion errors. The investigation expands our understanding of the underpinnings of PSI and frPSI intrusions in a large cohort.

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CA-ConvNeXt: Coordinate Attention on ConvNeXt for Early Alzheimer’s Disease Classification

Jin

Yin

Bai

et al. 2022

IFIP Advances in Information and Communication Technology

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A Web Platform for data acquisition and analysis for Alzheimer's disease

Cited by 10 publications

References 16 publications

Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia

Different aspects of failing to recover from proactive semantic interference predicts rate of progression from amnestic mild cognitive impairment to dementia

Semantic intrusion errors as a function of age, amyloid, and volumetric loss: a confirmatory path analysis

CA-ConvNeXt: Coordinate Attention on ConvNeXt for Early Alzheimer’s Disease Classification

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