Today, in Industry 4.0 and sensor‐rich environments, web‐based processing, and cloud computing have played significant roles in the quality systems designed to ensure product quality and reliability. Among quality validation technologies, variables acceptance sampling plans are essential tools in supply chain channels, where the variables quick‐switch sampling (VQSS) system is among the efficient schemes. The VQSS system comprises normal and tightened inspections that can provide a dynamic adjusting mechanism for lot disposition. Recently, the VQSS system regulated on process capability indices (PCIs) has been developed to integrate consumers' requirements into manufacturing processes. Unfortunately, the existing PCI‐based VQSS systems only consider a single, critical quality characteristic of the product. With advanced sensor technologies, cost‐efficiently measuring multiple quality characteristics (MQCs) has become a reality in today's manufacturing environments. Therefore, in this article, we emphasize developing the VQSS system with MQCs according to the overall PCI for lot disposition. By comparing the existing sampling plans, the proposed overall PCI‐based VQSS system can reduce the required sample size significantly. The results also demonstrate that the proposed system can accommodate both normal and tightened inspections' strengths to obtain a superior lot‐discrimination power. Furthermore, we have developed web‐based architecture and tools for practitioners to execute our proposed system efficiently in the cloud. They can be used to construct automation and semi‐automation applications for the lot disposition, which is appropriate in Industry 4.0 environments. Finally, a case of ultra‐mini chip resistors is illustrated to demonstrate the applicability of our designed VQSS system.