A Web-Based Research Tool for Functional Genomics of the Microcirculation: The Leukocyte Adhesion Cascade

LEY, K L A U S; BREWER, K E L L Y; MOTON, A L L E N

doi:10.1038/sj.mn.7300075

Cited by 3 publications

(2 citation statements)

References 21 publications

(31 reference statements)

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“…Parallel growth of computer storage and connectivity, as well as the desire of scientists to rapidly disseminate data, has resulted in the creation of valuable new information resources that will help to bridge the gap between basic genomic information, such as sequence and expression level, and the more traditionally described functional outcomes of experimental research. Databases range from general national resources such as the National Center for Biotechnology Information (28), animal-related sites such as the Rat Genome Database (31), sources for data and reagents (29) to single laboratory websites (23). These sites can provide essential information and tools for the analysis of data from physiological genomics experiments and as the availability of publicly accessible data- Figure 3.…”

Section: Informatics-in Silico Biologymentioning

confidence: 99%

Application of Physiological Genomics to the Microcirculation

Greene

2002

Microcirculation

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Physiological genomics represents a new challenge in the biological sciences-the quest to define the functions of thousands of genes that will emerge from the sequencing of the human genome and the genomes of other model organisms. Because the attention of the scientific community has focused on this task, new tools that will allow high-efficiency identification of gene function are being developed at remarkable speed. Physiological genomic approaches to understanding integrated systems function are now becoming widely used in many areas of biological research. The availability of genomic information across species has now revealed a striking degree of conservation of both gene order and function, allowing researchers to easily move from model organisms to man in the hunt for gene function. Physiological genomics approaches in the cardiovascular system have focused on disease-based models and the behavior of large vessels. In the microcirculation, genomic studies have largely been confined to the use of single gene knockouts or to the study of angiogenesis. This review summarizes the strategies for physiological genomics that are appropriate to the study of the microcirculation and discusses several key discoveries that have been made by using these approaches.

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Section: Informatics-in Silico Biologymentioning

confidence: 99%

Application of Physiological Genomics to the Microcirculation

Greene

2002

Microcirculation

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“…22,23 In such a case, often the only off-the-shelf software technology that is needed is Web-page indexing capability. For example, GeneCards, 24 built by a group at Israel's Weizmann Institute and mirrored at several sites such as the National Cancer Institute, uses the Excite engine to facilitate full-text search.…”

Section: Delivery Of Databases Dealing With Specialized Content Over mentioning

confidence: 99%

An introduction to information retrieval: applications in genomics

Nadkarni

2002

Pharmacogenomics J

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Information retrieval (IR) is the field of computer science that deals with the processing of documents containing free text, so that they can be rapidly retrieved based on keywords specified in a user's query. IR technology is the basis of Web-based search engines, and plays a vital role in biomedical research, because it is the foundation of software that supports literature search. Documents can be indexed by both the words they contain, as well as the concepts that can be matched to domain-specific thesauri; concept matching, however, poses several practical difficulties that make it unsuitable for use by itself. This article provides an introduction to IR and summarizes various applications of IR and related technologies to genomics.

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