A wearable origami-like paper-based electrochemical biosensor for sulfur mustard detection

Colozza, Noemi; Kehe, Kai; Dionisi, Giulio; Popp, Tanja; Tsoutsoulopoulos, Amelie; Steinritz, Dirk; Moscone, Danila; Arduini, Fabiana

doi:10.1016/j.bios.2019.01.002

Cited by 107 publications

(88 citation statements)

References 38 publications

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“…Spotting the analyte-specific enzymes (e.g., GOx, lactate oxidase or LOx, and uricase) helps determine the concentration of glucose, lactate, and uric acid, with a limit of detection of 0.21 ± 0.02 mM, 0.36 ± 0.03 mM, and 1.38 ± 0.13 mM, respectively. As a close distance between the working and reference electrodes minimizes the effect from uncompensated resistance between the two electrodes, screen printing that requires a stencil to pattern the electrodes limits the achievable maximum resolution [157][158][159][160].…”

Section: Paper-based Biosensorsmentioning

confidence: 99%

Recent Developments of Flexible and Stretchable Electrochemical Biosensors

Yang

Cheng

2020

Micromachines

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The skyrocketing popularity of health monitoring has spurred increasing interest in wearable electrochemical biosensors. Compared with the traditionally rigid and bulky electrochemical biosensors, flexible and stretchable devices render a unique capability to conform to the complex, hierarchically textured surfaces of the human body. With a recognition element (e.g., enzymes, antibodies, nucleic acids, ions) to selectively react with the target analyte, wearable electrochemical biosensors can convert the types and concentrations of chemical changes in the body into electrical signals for easy readout. Initial exploration of wearable electrochemical biosensors integrates electrodes on textile and flexible thin-film substrate materials. A stretchable property is needed for the thin-film device to form an intimate contact with the textured skin surface and to deform with various natural skin motions. Thus, stretchable materials and structures have been exploited to ensure the effective function of a wearable electrochemical biosensor. In this mini-review, we summarize the recent development of flexible and stretchable electrochemical biosensors, including their principles, representative application scenarios (e.g., saliva, tear, sweat, and interstitial fluid), and materials and structures. While great strides have been made in the wearable electrochemical biosensors, challenges still exist, which represents a small fraction of opportunities for the future development of this burgeoning field.

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Section: Paper-based Biosensorsmentioning

confidence: 99%

Recent Developments of Flexible and Stretchable Electrochemical Biosensors

Yang

Cheng

2020

Micromachines

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“…An area in which screen-printed paper electrodes have shown particular relevance is environmental monitoring ( Table 1 ). Different types of paper impregnated with suitable reagents [ 10 ], modified with metal nanoparticles or carbon nanostructures both in the absence or in the presence [ 11 ] of specific enzymes, have been used to determine contaminants such as heavy metals [ 12 ], anions [ 13 ], and gases [ 14 , 15 ]. For instance, the electrocatalytic activity of polyoxymetalates (POMs) toward the electrochemical reduction of chlorate was employed to prepare a vanadium-containing POM ([PMO 11 VO 40 ] 5− ) for the determination of ClO 3 − in soils.…”

Section: Screen-printed Paper Electrochemical (Bio)sensorsmentioning

confidence: 99%

“…A Keithley 2400 current source meter (Keithley Co., Cleveland, OH, USA) was used to measure the electrical properties and sensing performance of the conductive papers. The LOD attained in the aerosol phase was 0.019 g min m −3 [ 11 ].…”

Section: Screen-printed Paper Electrochemical (Bio)sensorsmentioning

confidence: 99%

Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing

2020

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Screen-printing technology has revolutionized many fields, including that of electrochemical biosensing. Due to their current relevance, this review, unlike other papers, discusses the relevant aspects of electrochemical biosensors manufactured using this technology in connection to both paper substrates and wearable formats. The main trends, advances, and opportunities provided by these types of devices, with particular attention to the environmental and biomedical fields, are addressed along with illustrative fundamentals and applications of selected representative approaches from the recent literature. The main challenges and future directions to tackle in this research area are also pointed out.

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“…A variety of species belong to this group, including gaseous blood or chocking agents, volatile nerve and blister agents, nonvolatile vomiting agents, and nonvolatile lachrymators (tear gases). Recently, a wearable origami-like paper-based electrochemical biosensor for the determination of sulfur mustard (commonly known as mustard gas) directly in the aerosol and liquid phase was reported [129]. The electrodes were prepared by screen-printing onto a filter-paper support, and the detection was based on the inhibitory effects toward the enzymatic oxidation of choline catalyzed by choline oxidase, followed by detection of the reaction product, H 2 O 2 .…”

Section: Chemical Warfare Agents (Cwas)mentioning

confidence: 99%

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

et al. 2019

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This article critically discusses the latest advances in the use of voltammetric, amperometric, potentiometric, and impedimetric biosensors for forensic analysis. Highlighted examples that show the advantages of these tools to develop methods capable of detecting very small concentrations of analytes and provide selective determinations through analytical responses, without significant interferences from other components of the samples, are presented and discussed, thus stressing the great versatility and utility of electrochemical biosensors in this growing research field. To illustrate this, the determination of substances with forensic relevance by using electrochemical biosensors reported in the last five years (2015–2019) are reviewed. The different configurations of enzyme or affinity biosensors used to solve analytical problems related to forensic practice, with special attention to applications in complex samples, are considered. Main prospects, challenges to focus, such as the fabrication of devices for rapid analysis of target analytes directly on-site at the crime scene, or their widespread use and successful applications to complex samples of interest in forensic analysis, and future efforts, are also briefly discussed.

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A wearable origami-like paper-based electrochemical biosensor for sulfur mustard detection

Cited by 107 publications

References 38 publications

Recent Developments of Flexible and Stretchable Electrochemical Biosensors

Recent Developments of Flexible and Stretchable Electrochemical Biosensors

Screen-Printed Electrodes: Promising Paper and Wearable Transducers for (Bio)Sensing

What Electrochemical Biosensors Can Do for Forensic Science? Unique Features and Applications

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