A wearable graphene transistor-based biosensor for monitoring IL-6 biomarker

Laliberte, KaitlynE.; Scott, Patrick G.; Khan, Niazul Islam; Mahmud, M.D. Shaad; Song, Edward

doi:10.1016/j.mee.2022.111835

Cited by 16 publications

(9 citation statements)

References 26 publications

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“…These sensitivity values obtained are even more significant if the low volume of the sample used is considered, which is the smallest one (2 μL) reported. 37 , 38 , 59 On the contrary, the recognition times were somewhat higher than those reported in other works, 38 , 57 − 60 but this cannot be identified as a weakness since they are of the same order. Furthermore, it is important to indicate that this may be due to the low volume of sample tested.…”

Section: Resultscontrasting

confidence: 71%

“…Our approach constitutes the first MM reported in the literature for the determination of IL-6. Compared to other works found in the literature of aptassays developed for the determination of IL-6, 37 , 38 , 57 − 60 it can be said that our approach allows to obtain one of the highest sensitivities found in the literature (LOD = 0.02 pg mL –1 ), allowing the determination of IL-6 in unique clinical samples, which are reported here for the first time, giving value to MM technology for diagnostic tests. These sensitivity values obtained are even more significant if the low volume of the sample used is considered, which is the smallest one (2 μL) reported.…”

Section: Resultsmentioning

confidence: 55%

“…Compared to other works found in the literature of aptassays developed for the determination of IL-6, ,,− it can be said that our approach allows to obtain one of the highest sensitivities found in the literature (LOD = 0.02 pg mL –1 ), allowing the determination of IL-6 in unique clinical samples, which are reported here for the first time, giving value to MM technology for diagnostic tests. These sensitivity values obtained are even more significant if the low volume of the sample used is considered, which is the smallest one (2 μL) reported. ,, On the contrary, the recognition times were somewhat higher than those reported in other works, ,− but this cannot be identified as a weakness since they are of the same order. Furthermore, it is important to indicate that this may be due to the low volume of sample tested.…”

Section: Resultsmentioning

confidence: 57%

“…IL-6 has been determined by different approaches, such as chemiluminescent immunoassay, , colorimetric immunoassay, electrochemical immunosensor, − liquid-gated field-effect transistor, fluorescence immunoassay, − and surface plasmon resonance biosensor, − and with the use of aptamers (micro-array, impedance, and UV–vis spectrophotometry) ,,− among others.…”

mentioning

confidence: 99%

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On the Move-Sensitive Fluorescent Aptassay on Board Catalytic Micromotors for the Determination of Interleukin-6 in Ultra-Low Serum Volumes for Neonatal Sepsis Diagnostics

et al. 2022

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A graphene oxide/nickel/platinum nanoparticle micromotor (MM)-based fluorescent aptassay is proposed to determine interleukin-6 (IL-6) in serum samples from low-birth-weight infants (gestational age of less than 32 weeks and birthweight below 1000 g) with sepsis suspicion. In this kind of patients, IL-6 has demonstrated good sensitivity and specificity for the diagnosis of sepsis, both for early and late onset sepsis. The approach was based on the adsorption of the aptamer for IL-6 tagged with 6-FAM as a fluorescent label (AptIL‑6, λem = 520 nm) on the graphene oxide external layer (MMGO–AptIL‑6) inducing fluorescence quenching (OFF state) and a subsequent on-the-move affinity recognition of IL-6 from AptIL‑6 (IL-6–AptIL‑6 complex) recovering the fluorescence (ON state). An aptamer against IL-6 was selected and developed by the systematic evolution of ligands by exponential enrichment technology. This approach displayed a suitable linear range of 0.07–1000 pg mL–1 (r = 0.995) covering the cut-off and clinical practice levels, allowing direct determination without any dilution and simplifying the analysis as well as exhibiting an excellent sensitivity (LOD = 0.02 pg mL–1) in ultralow volumes of diagnostic clinical samples (2 μL). A high agreement between IL-6 levels obtained from our MM-based approach and the method used by the Hospital was obtained (relative error < 3%). The MM-based aptassay is competitive in comparison with that of the Hospital, in terms of a significant reduction of the sample volume (15 times less) and enhanced sensitivity, employing similar analysis times. These results position MM technology with enough potential to achieve high sensitivities in low sample volumes, opening new avenues in diagnosis based on low sample volumes.

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Section: Resultscontrasting

confidence: 71%

Section: Resultsmentioning

confidence: 55%

Section: Resultsmentioning

confidence: 57%

mentioning

confidence: 99%

See 2 more Smart Citations

On the Move-Sensitive Fluorescent Aptassay on Board Catalytic Micromotors for the Determination of Interleukin-6 in Ultra-Low Serum Volumes for Neonatal Sepsis Diagnostics

et al. 2022

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“…Biosensors with programmed diagnostic functions can measure, for instance, blood temperature, pressure, pH, glucose concentration, hormonal, and alcohol levels, and are becoming more and more popular. They can also can be used to detect human movement, or small toxic molecules [ 75 , 76 , 77 , 78 ]. Biosensors usually attach to specified positions in the human body, where important biomarkers (e.g., pressure, alcohol level) can be best collected.…”

Section: Numerical Resultsmentioning

confidence: 99%

Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Zhang

Qiu

Elkhodary

et al. 2022

Gels

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Hydrogels are nowadays widely used in various biomedical applications, and show great potential for the making of devices such as biosensors, drug- delivery vectors, carriers, or matrices for cell cultures in tissue engineering, etc. In these applications, due to the irregular complex surface of the human body or its organs/structures, the devices are often designed with a small thickness, and are required to be flexible when attached to biological surfaces. The devices will deform as driven by human motion and under external loading. In terms of mechanical modeling, most of these devices can be abstracted as shells. In this paper, we propose a mixed graph-finite element method (FEM) phase field approach to model the fracture of curved shells composed of hydrogels, for biomedical applications. We present herein examples for the fracture of a wearable biosensor, a membrane-coated drug, and a matrix for a cell culture, each made of a hydrogel. Used in combination with experimental material testing, our method opens a new pathway to the efficient modeling of fracture in biomedical devices with surfaces of arbitrary curvature, helping in the design of devices with tunable fracture properties.

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Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

Han,

Choi,

Kang

2024

Adv Healthcare Materials

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Transdermal healthcare systems have gained significant attention for their painless and convenient drug administration, as well as their ability to detect biomarkers promptly. However, the skin barrier limits the candidates of biomolecules that can be transported, and reliance on simple diffusion poses a bottleneck for personalized diagnosis and treatment. Consequently, recent advancements in transdermal transport technologies have evolved toward active methods based on external energy sources. Multiple combinations of these technologies have also shown promise for increasing therapeutic effectiveness and diagnostic accuracy as delivery efficiency is maximized. Furthermore, wearable healthcare platforms are being developed in diverse aspects for patient convenience, safety, and on‐demand treatment. Herein, a comprehensive overview of active transdermal delivery technologies is provided, highlighting the combination‐based diagnostics, therapeutics, and theragnostics, along with the latest trends in platform advancements. This offers insights into the potential applications of next‐generation wearable transdermal medical devices for personalized autonomous healthcare.

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A wearable graphene transistor-based biosensor for monitoring IL-6 biomarker

Cited by 16 publications

References 26 publications

On the Move-Sensitive Fluorescent Aptassay on Board Catalytic Micromotors for the Determination of Interleukin-6 in Ultra-Low Serum Volumes for Neonatal Sepsis Diagnostics

On the Move-Sensitive Fluorescent Aptassay on Board Catalytic Micromotors for the Determination of Interleukin-6 in Ultra-Low Serum Volumes for Neonatal Sepsis Diagnostics

Modeling Tunable Fracture in Hydrogel Shell Structures for Biomedical Applications

Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

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