A wearable battery-free wireless and skin-interfaced microfluidics integrated electrochemical sensing patch for on-site biomarkers monitoring in human perspiration

Zhang, Shi-Peng; Zahed, Md Abu; Sharifuzzaman, Md.; Yoon, Sanghyuk; Xue, Hui; Barman, Sharat Chandra; Sharma, Sudeep; Yoon, Hyo Sang; Park, Chani; Park, Jae Yeong

doi:10.1016/j.bios.2020.112844

Cited by 82 publications

(62 citation statements)

References 36 publications

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“…The on-body monitoring of sodium and chloride ions in sweat can be utilized to indicate dehydration status and to diagnose cystic fibrosis [25,26]. The potassium level in sweat is related to muscle activity [27], and pH monitoring can be used for the management of chronic wounds [28]. A number of wearable sweat sensors have recently been developed in many different device forms, such as multi-sensor arrays [29], textile-based potentiometric sensors [30], smart bandages [31], patches [32], and tattoos [33], and these sensors are capable of monitoring electrolytes, metabolites, heavy metals, and toxic gases in human body fluids [34][35][36].…”

Section: Introductionmentioning

confidence: 99%

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

et al. 2021

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Highlights Ultrathin and defect-free graphene ink is prepared through a high-throughput fluid dynamics process, resulting in a high exfoliation yield (53.5%) and a high concentration (47.5 mg mL−1). A screen-printed graphene conductor exhibits a high electrical conductivity of 1.49 × 104 S m−1 and good mechanical flexibility. An electrochemical sodium ion sensor based on graphene ink exhibits an excellent potentiometric sensing performance in a mechanically bent state. Real-time monitoring of sodium ion concentration in sweat is demonstrated. Abstract Conductive inks based on graphene materials have received significant attention for the fabrication of a wide range of printed and flexible devices. However, the application of graphene fillers is limited by their restricted mass production and the low concentration of their suspensions. In this study, a highly concentrated and conductive ink based on defect-free graphene was developed by a scalable fluid dynamics process. A high shear exfoliation and mixing process enabled the production of graphene at a high concentration of 47.5 mg mL−1 for graphene ink. The screen-printed graphene conductor exhibits a high electrical conductivity of 1.49 × 104 S m−1 and maintains high conductivity under mechanical bending, compressing, and fatigue tests. Based on the as-prepared graphene ink, a printed electrochemical sodium ion (Na+) sensor that shows high potentiometric sensing performance was fabricated. Further, by integrating a wireless electronic module, a prototype Na+-sensing watch is demonstrated for the real-time monitoring of the sodium ion concentration in human sweat during the indoor exercise of a volunteer. The scalable and efficient procedure for the preparation of graphene ink presented in this work is very promising for the low-cost, reproducible, and large-scale printing of flexible and wearable electronic devices.

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Section: Introductionmentioning

confidence: 99%

Highly Concentrated, Conductive, Defect-free Graphene Ink for Screen-Printed Sensor Application

et al. 2021

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“…Zhang et al [ 191 ] developed a sensor for analytes in human sweat based on MWCNTs and MXene-Ti 3 C 2 T x . Carbon paste electrodes were fabricated on a flexible polyethylene terephthalate (PET) substrate and MWCNTs drop-cast on the electrodes, followed by the MXene.…”

Section: Biosensors Based On Carbon Nanotubesmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Carbon Nanotube (CNT)-Based Biosensors

2021

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This review focuses on recent advances in the application of carbon nanotubes (CNTs) for the development of sensors and biosensors. The paper discusses various configurations of these devices, including their integration in analytical devices. Carbon nanotube-based sensors have been developed for a broad range of applications including electrochemical sensors for food safety, optical sensors for heavy metal detection, and field-effect devices for virus detection. However, as yet there are only a few examples of carbon nanotube-based sensors that have reached the marketplace. Challenges still hamper the real-world application of carbon nanotube-based sensors, primarily, the integration of carbon nanotube sensing elements into analytical devices and fabrication on an industrial scale.

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“…A battery-free wearable microuidic integrated skin mountable electrochemical self-powered sensor was fabricated, which could monitor the K + (potassium ion) level by harvesting human sweat and transmit the real-time data through NFC (near eld communication) wirelessly. 127 A schematic of the sensor structure is shown in Fig. 12e (le side image), presenting multiwalled carbon nanotubes (MWCNTs) and MXene-Ti 3 C 2 T x -based three-dimensional internal structure with the used components.…”

Section: Applications Of Electrochemistry-based Redox Devicesmentioning

confidence: 99%