A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan

Kusakabe, Atsunori; Tanaka, Yasuhito; Orito, Etsuro; Sugauchi, Fuminaka; Kurbanov, Fuat; Sakamoto, Tomoyuki; Shinkai, Noboru; Hirashima, Noboru; Hasegawa, Izumi; Ohno, Tomoyoshi; Ueda, Ryuzo; Mizokami, Masashi

doi:10.1007/s00535-006-1999-3

Cited by 29 publications

(22 citation statements)

References 30 publications

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“…The analysis of the characteristics of NBNC HCC indicated that the mean age, rate of complications associated with diabetes and BMI were significantly higher in these cases compared with cases of virus-related HCC, in agreement with previous reports (5)(6)(7)(8)(9)(10)(11)(12). Patients with NBNC HCC exhibited a good liver function, although a number of patients presented with a large tumor size (6), possibly as they were not examined periodically due to the absence of hepatitis virus infection.…”

Section: Discussionsupporting

confidence: 91%

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

et al. 2015

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Abstract. The present study investigated the clinicopathological characteristics of resected hepatitis B virus surface antigen (HBs-Ag)-negative, hepatitis C virus antibody (HCV-Ab)-negative hepatocellular carcinoma (NBNC HCC). The clinicopathological characteristics of 164 patients with NBNC HCC, 144 patients with HBs-Ag-positive HCC (HBV group) and 550 patients with HCV-Ab-positive HCC (HCV group) were compared. In the NBCN HCC group, 61 patients succumbed after 2 years. Subsequently, NBCN HCC patients were compared according to survival time (<2 years, 39 patients vs. ≥2 years, 64 patients) to identify prognostic factors. Finally, the clinicopathological characteristics of NBNC HCC were compared according to history of alcohol abuse/pathological results: Non-alcoholic steatohepatitis HCC (NASH group, 40 patients), alcohol abuse HCC (AL group, 80 patients) and other HCCs (non-NASH/non-AL group, 44 patients). Age, diabetes prevalence and body mass index were significantly higher for NBNC HCC compared with virus-related HCC. Among stage II cases, the prognosis was significantly better for the NBNC compared with that for the HCV group. A high α-fetoprotein level, poorly differentiated HCC and advanced liver fibrosis were independent risk factors for the prognosis of NBNC HCC. The proportion of female patients was significantly higher among NASH compared with AL HCC patients. The cumulative survival rates following surgery were similar in the NASH, AL and non-NASH/non-AL groups. NBNC HCC is considered to be a lifestyle disease, with better prognosis for stage II patients. The prognostic factors for NBNC HCC patients undergoing hepatectomy were similar to those with virus-related HCC and did not differ according to alcohol abuse history or pathological results.

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Section: Discussionsupporting

confidence: 91%

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

et al. 2015

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“…The HBV DNA level in individuals with cryptogenic liver disease is generally less than 10 4 copies/ml (38). While the causal role of occult HBV infection in cryptogenic liver disease and chronic hepatitis is still debated (37,116,144), the usefulness of monitoring liver enzymes and HBV DNA levels in the management of occult HBV infection has been demonstrated (39). However, specific guidelines for the management of occult HBV-related liver diseases are yet to evolve.…”

Section: Clinical Relevancementioning

confidence: 99%

“…Occult HBV infections are detected in as many as 73% of HCVrelated HCC patients (188,250) and at a lower frequency (18%) in non-B non-C HCC (NBNC HCC) (144). The occult HBV sequences from NBNC HCC lack core promoter mutations that are frequently detected in HBsAg-positive HCC.…”

Section: Clinical Relevancementioning

confidence: 99%

“…In addition, diabetes and obesity are frequently detected in the NBNC HCC group compared to the HBsAg-positive HCC group. The authors argue that a higher incidence of nonalcoholic steatohepatitis in the NBNC HCC group weakens the causal association of occult HBV infection in the development of HCC (144). The presence of core promoter mutations in occult HBV genomes in HCV-related HCC argues for a contributory role of occult HBV infections in the pathogenesis of HCC (188).…”

Section: Clinical Relevancementioning

confidence: 99%

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Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection

2012

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SUMMARY Chronic hepatitis B virus (HBV) infection is a complex clinical entity frequently associated with cirrhosis and hepatocellular carcinoma (HCC). The persistence of HBV genomes in the absence of detectable surface antigenemia is termed occult HBV infection. Mutations in the surface gene rendering HBsAg undetectable by commercial assays and inhibition of HBV by suppression of viral replication and viral proteins represent two fundamentally different mechanisms that lead to occult HBV infections. The molecular mechanisms underlying occult HBV infections, including recently identified mechanisms associated with the suppression of HBV replication and inhibition of HBV proteins, are reviewed in detail. The availability of highly sensitive molecular methods has led to increased detection of occult HBV infections in various clinical settings. The clinical relevance of occult HBV infection and the utility of appropriate diagnostic methods to detect occult HBV infection are discussed. The need for specific guidelines on the diagnosis and management of occult HBV infection is being increasingly recognized; the aspects of mechanistic studies that warrant further investigation are discussed in the final section.

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“…Hepatocellular carcinoma (HCC) is one of the most common types of malignant tumor worldwide, and is the third leading cause of cancer-associated mortality, after lung and colon cancer (1)(2)(3)(4). It is one of the most aggressive human malignancies and previous data have shown that the five-year survival rate is poor (5).…”

Section: Introductionmentioning

confidence: 99%

Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells

Sun

Peng

et al. 2014

Molecular Medicine Reports

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Abstract.Icaritin is an active ingredient derived from the plant Herba epimedium, which exhibits various pharmacological and biological activities. However, the function, and the underlying mechanisms of icaritin on the growth of SMMC-7721 human hepatoma cells have yet to be elucidated. The present study aimed to investigate the function and underlying mechanisms of icaritin in the growth of SMMC-7721 cells. The cells were treated with varying concentrations of icaritin for 12, 24 and 48 h, respectively, prior to cytotoxic analysis. Apoptosis of SMMC-7721 cells following treatment with icaritin was measured using flow cytometry. The gene expression of mitochondria-and Fas-mediated caspase-dependent pathways was detected by reverse transcription-quantitative polymerase chain reaction and western blotting. Statistical analysis was performed by Student's t-test and one-way analysis or variance. The present study demonstrated that treatment with icaritin significantly inhibited growth, and induced apoptosis of SMMC-7721 cells, in a time-and dose-dependent manner. In addition, icaritin triggered the mitochondrial/caspase apoptotic pathway, by decreasing the Bcl-2/Bax protein ratio and increasing activation of caspase-3. Icaritin also activated the Fas-mediated apoptosis pathway, as was evident by the increased expression levels of Fas and activation of caspase-8. These data suggest that icaritin may be a potent growth inhibitor and induce apoptosis of SMMC-7721 cells through the mitochondria-and Fas-mediated caspase-dependent pathways. The present study may provide experimental evidence for preclinical and clinical evaluations of icaritin for HCC therapy.

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A weak association between occult HBV infection and non-B non-C hepatocellular carcinoma in Japan

Abstract: A weak association between occult HBV infection and HCC development was observed in the NBNC patients. This study indicates that nonalcoholic steato-hepatitis should be further investigated to assess its contribution to HCC development in this category of patients.

Cited by 29 publications

References 30 publications

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

Clinicopathological characteristics of hepatitis B surface antigen-negative and hepatitis C antibody-negative hepatocellular carcinoma

Molecular Mechanisms Underlying Occult Hepatitis B Virus Infection

Anticancer agent icaritin induces apoptosis through caspase-dependent pathways in human hepatocellular carcinoma cells

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