A-waves in Guillain–Barré syndrome: Correlation with electrophysiological subtypes and antiganglioside antibodies

Kawakami, S.; Sonoo, Masahiro; Kadoya, Akiko; Chiba, Atsuro; Shimizu, Teruo

doi:10.1016/j.clinph.2011.10.005

Cited by 17 publications

(16 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Electrodiagnoses were made using Viking Quest (EMG & Evoked Potential Response Unit, Nicolet, NE, USA), the standard method at our institute. Electrophysiological examinations included NCS and F-wave assessments, which all patients underwent 10–14 days after the beginning of symptoms [ 11 , 12 ]. Limb temperature was maintained above 32 °C with a heater, if needed.…”

Section: Methodsmentioning

confidence: 99%

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

Xiao

Ding

et al. 2017

BMC Neurol

View full text Add to dashboard Cite

BackgroundPost-traumatic Guillain-Barré syndrome (GBS) is a rarely described potentially life-threatening cause of weakness. We sought to elucidate the clinical features and electrophysiological patterns of post-traumatic GBS as an aid to diagnosis.MethodsWe retrospectively studied six patients diagnosed with post-traumatic GBS between 2014 and 2016 at Tianjin Medical University General Hospital, China. Clinical features, serum analysis, lumbar puncture results, electrophysiological examinations, and prognosis were assessed.ResultsAll six patients had different degrees of muscular atrophy at nadir and in two, respiratory muscles were involved. Five also had damaged cranial nerves and four of these had serum antibodies against gangliosides. The most common electrophysiological findings were relatively normal distal latency, prominent reduction of compound muscle action potential amplitude, and absence of F-waves, which are consistent with an axonal form of GBS.ConclusionsIt is often overlooked that GBS can be triggered by non-infectious factors such as trauma and its short-term prognosis is poor. Therefore, it is important to analyze the clinical and electrophysiological features of GBS after trauma. Here we have shown that electrophysiological evaluations are helpful for diagnosing post-traumatic GBS. Early diagnosis may support appropriate treatment to help prevent morbidity and improve prognosis.

show abstract

Section: Methodsmentioning

confidence: 99%

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

Xiao

Ding

et al. 2017

BMC Neurol

View full text Add to dashboard Cite

show abstract

“…4 5 We suggested that abundant A-waves can be a novel marker of demyelination. 1 In order to know which criteria best reflect the pathophysiology, we need some external gold standard. In this study, we adopted the time course of median DML as such a gold standard.…”

Section: Discussionmentioning

confidence: 99%

“…The abundant A-waves were defined as three or more identifiable peaks between the CMAP and F-waves, observed in the median or ulnar nerves at least once during weeks 3-6 from onset. 1 Clinical features of patients with abundant A-waves were compared with those without.…”

Section: Methodsmentioning

confidence: 99%

“…1 The first criterion was the abundant A-waves, which were positive in 9 and negative in 21patients. The second was Ho's criteria, 3 applied to the nerve conduction study (NCS) results at weeks 3-6 from onset, which classified patients into 14 AIDP and 16 non-AIDP (AMAN or unclassified) groups.…”

Section: Methodsmentioning

confidence: 99%

“…We recently suggested that abundant A-waves in Guillain-Barré syndrome (GBS) can be a novel marker of demyelination because they were strongly correlated with the acute inflammatory demyelinating polyneuropathy (AIDP) subtype and the absence of anti-glycolipid antibodies. 1 Hiraga et al 2 reported that patients with AIDP without anti-ganglioside antibodies showed progressive prolongation of the distal motor latency (DML) of the median nerve, whereas the DML of patients with AIDP with anti-ganglioside antibodies may initially be prolonged but rapidly return to normal, suggesting an essentially axonal pathology. These results imply the possibility that the time course of DML of the median nerve (median DML) can be used as another marker of demyelination.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The correlation between the change of distal motor latency of the median nerve and the abundant A-waves in Guillain-Barré syndrome

Kadoya

Ogawa

Kawakami

et al. 2015

J Neurol Neurosurg Psychiatry

Self Cite

View full text Add to dashboard Cite

Utilizing nerve conduction studies to identify very early Guillain–Barré syndrome and distinguish it from mimics in emergency settings

John,

Mathew

2024

Muscle and Nerve

View full text Add to dashboard Cite

Introduction/AimsAccurately diagnosing Guillain–Barré syndrome (GBS) in its early stages and distinguishing it from mimics poses challenges. This study aimed to evaluate the utility of an existing electrodiagnostic criterion in very early GBS (VEGBS) for discerning mimics. Additionally, we explored specific electrophysiological abnormalities in VEGBS to design a new diagnostic criterion for more accurate VEGBS diagnosis.MethodsWe retrospectively identified all patients with flaccid quadriparesis initially suspected of GBS who underwent nerve conduction studies (NCS) ≤4 days from symptom onset. We then retrieved their NCS data and applied an existing electrodiagnostic criterion for sensitivity and specificity analyses based on the final discharge diagnosis. Furthermore, we designed a new criterion based on the observed electrophysiological abnormalities that have maximum specificity and at least 50% sensitivity.ResultsAmong 70 patients suspected of VEGBS, 44 (63%) received a final diagnosis of GBS, while in 26 (37%), the GBS diagnosis was later refuted. Umapathi's definite criterion exhibited a sensitivity of 61.36% and a specificity of 92.31%. The probable and possible groups showed very high sensitivity (90.91% and 100%, respectively); however, specificity was low (57.69% and 30.77%, respectively) in the very early stage. Our proposed criterion demonstrated a sensitivity of 88.64% (CI: 75.44%–96.21%) and a specificity of 96.15% (CI: 80.36%–99.90%).DiscussionThe criterion based on presumed electrophysiological correlates of specific early GBS pathophysiology proved more effective than the existing electrodiagnostic criterion in differentiating VEGBS from mimics.

show abstract

A-waves in Guillain–Barré syndrome: Correlation with electrophysiological subtypes and antiganglioside antibodies

Cited by 17 publications

References 35 publications

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

Clinical and electrophysiological features of post-traumatic Guillain-Barré syndrome

The correlation between the change of distal motor latency of the median nerve and the abundant A-waves in Guillain-Barré syndrome

Utilizing nerve conduction studies to identify very early Guillain–Barré syndrome and distinguish it from mimics in emergency settings

Contact Info

Product

Resources

About