Background: Water-related, including waterborne, diseases remain important sources of morbidity and mortality worldwide, but particularly in developing countries. The potential for changes in disease associated with predicted anthropogenic climate changes make water-related diseases a target for prevention. Methods: We provide an overview of evidence on potential future changes in water-related disease associated with climate change. Results: A number of pathogens are likely to present risks to public health, including cholera, typhoid, dysentery, leptospirosis, diarrhoeal diseases and harmful algal blooms (HABS). The risks are greatest where the climate effects drive population movements, conflict and disruption, and where drinking water supply infrastructure is poor. The quality of evidence for water-related disease has been documented. Conclusions: We highlight the need to maintain and develop timely surveillance and rapid epidemiological responses to outbreaks and emergence of new waterborne pathogens in all countries. While the main burden of waterborne diseases is in developing countries, there needs to be both technical and financial mechanisms to ensure adequate quantities of good quality water, sewage disposal and hygiene for all. This will be essential in preventing excess morbidity and mortality in areas that will suffer from substantial changes in climate in the future.Atmosphere 2018, 9, 385 2 of 60 which do not suffer the consequences of extreme events to the same extent [4]. Due to the lifetime of greenhouse gases such as carbon dioxide in the atmosphere, and the timescales associated with ocean warming, even if global CO 2 emissions were curtailed immediately, the effects on the earth's climate, including increasing temperatures and sea level rise would continue for a number of decades before starting to plateau [2]. However, this should be seen as a general call to action to reduce emissions as soon as possible, given that the impacts are likely to extend beyond current conditions and there are indications that economic investment now will be likely to reduce costs later [5]. There is also a need to develop adaptations to cope with changes in climate. Recent research highlighting the health benefits of limiting future temperature rises to the more ambitious target of 1.5 • C rather than 2 • C, in line with the Paris agreement of 2016, further emphasises the need to limit emissions [6].Climate change affects health in a number of ways, and the impacts vary both geographically and between different populations. A growing and ageing population in much of the world means that the proportion of the population who are vulnerable to the effects of climate change will increase in the future [7]. The most direct impacts from climate change are from the effects of high temperatures, and from acute impacts relating to extreme events such as storms, floods and heatwaves. These physical or meteorological stressors can produce direct health effects, such as physical injury, illness, or mental health impacts du...