A Waterborne Outbreak of Shigella sonnei with Resistance to Azithromycin and Third-Generation Cephalosporins in China in 2015

Ma, Qiuxia; Xu, Xuebin; Luo, Ming; Wang, Jian; Yang, Chaojie; Hu, Xin; Liang, Beibei; Wu, Fuli; Yang, Xiaoxia; Wang, Jinyan; Liu, Hongbo; Wen, Li; Zhong, Yu; Li, Peng; Xie, Jing; Jia, Leili; Wang, Ligui; Hao, Rongzhang; Du, Xinying; Qiu, Shaofu; Song, Hongbin; Sun, Yansong

doi:10.1128/aac.00308-17

Cited by 31 publications

(18 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…IncI and IncB/O plasmids belong to the IncIcomplex (IncI, IncB/O, IncK, IncZ), which have comparable antisense RNA plasmid replication control mechanisms 12 . Our results concur with previous reports that proposed a commonality of IncI-complex plasmids associated with the bla CTX-M element in S. sonnei from countries at various stages of economic development 8,11,[13][14][15][16][17] . The sampling of these plasmids by cipR S. sonnei could be attributed to several factors, including the close genetic relatedness between Shigella and E. coli, the propensity of S. sonnei to acquire AMR plasmids, and the circulation of highly transmissible AMR plasmids in commensal E. coli.…”

supporting

confidence: 93%

Commensal Escherichia coli are a reservoir for the transfer of XDR plasmids into epidemic fluoroquinolone-resistant Shigella sonnei

et al. 2020

View full text Add to dashboard Cite

Data Availability All raw genomic data that support the findings of this study have been deposited in the European Nucleotide Archive (project: PRJEB30967) and can be accessed via this link (https://www.ebi.ac.uk/ena/data/search?query=PRJEB30967). Details about accession numbers of S. sonnei isolates can be found in Supplementary Table 1. The S. sonnei reference genome Ss046 chromosome (accession number: NC_007382), virulence plasmid pSs046 (accession number: NC_007385.1) and three small plasmids commonly found in global lineage III S. sonnei: spA (accession number: NC_009345.1), spB (accession number: NC_009346.1), and spC (accession number: NC_009347.1) were downloaded from GenBank. Raw MinION reads for plasmid p01_0123 are deposited in ENA (accession number: ERS3050922). Source data for main figures [Figs. 2a, 3a, 4] and Extended Data [ED Figs. 1, 2] are provided with the paper. Additional data that support the findings of this study are available from the corresponding author upon request. Author contributions PTD, MAR, and SB designed the study. PTD performed data analysis and interpreted the results under the scientific guidance of MAR and SB. PTD drafted the paper, with MAR and SB revising and structuring the paper. PTD and HNDT performed whole genome sequencing. PTD and TNTN performed plasmid isolation, digestion and sequencing. PTD, FA, and TNTN performed the plasmid conjugation experiments. HTT performed basic microbiology work. HCT and CB assisted in the design of laboratory experiments. DVT recruited patients and performed the clinical work required for the study. HCT, CB, and GET contributed to the editing of the paper. All authors read and approved the final draft.

show abstract

supporting

confidence: 93%

Commensal Escherichia coli are a reservoir for the transfer of XDR plasmids into epidemic fluoroquinolone-resistant Shigella sonnei

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The findings in this study associated the outbreak to multidrug-resistant Salmonella enterica serovar Typhi ingested through well water that served as the sole source of drinking water in the community, but was unacceptably polluted with dead and decaying bodies of animal, fecal material, and garbage. Similarly, Ma et al [ 287 ] reported the waterborne outbreak of shigellosis in China caused by Shigella sonnei with resistance to azithromycin, and third class cephalospsorins, due to mph (A) and bla CTX-M-14 -harboring IncB/O/K/Z group transmissible plasmid. In addition, Akoachere et al [ 288 ] unravelled the persistence of multidrug-resistant toxigenic Vibrio cholerae O1 in water samples (taps, dug wells, and streams) collected from New Bell—Doula, and associated these bacteria strains with the 2010–2011 cholera epidemic that recorded the highest number of death cases in the Littoral province of Cameroon.…”

Section: The Great Challenge: Antibiotics Resistancementioning

confidence: 99%

Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications

et al. 2018

View full text Add to dashboard Cite

Due to the increased demand of animal protein in developing countries, intensive farming is instigated, which results in antibiotic residues in animal-derived products, and eventually, antibiotic resistance. Antibiotic resistance is of great public health concern because the antibiotic-resistant bacteria associated with the animals may be pathogenic to humans, easily transmitted to humans via food chains, and widely disseminated in the environment via animal wastes. These may cause complicated, untreatable, and prolonged infections in humans, leading to higher healthcare cost and sometimes death. In the said countries, antibiotic resistance is so complex and difficult, due to irrational use of antibiotics both in the clinical and agriculture settings, low socioeconomic status, poor sanitation and hygienic status, as well as that zoonotic bacterial pathogens are not regularly cultured, and their resistance to commonly used antibiotics are scarcely investigated (poor surveillance systems). The challenges that follow are of local, national, regional, and international dimensions, as there are no geographic boundaries to impede the spread of antibiotic resistance. In addition, the information assembled in this study through a thorough review of published findings, emphasized the presence of antibiotics in animal-derived products and the phenomenon of multidrug resistance in environmental samples. This therefore calls for strengthening of regulations that direct antibiotic manufacture, distribution, dispensing, and prescription, hence fostering antibiotic stewardship. Joint collaboration across the world with international bodies is needed to assist the developing countries to implement good surveillance of antibiotic use and antibiotic resistance.

show abstract

“…Strong [355,[580][581][582][583][584] Waterborne OI [284] Torovirus Toroviruses are enveloped viruses that have been linked to enteric infections in horses (Berne virus), cattle (Breda virus), pigs, and humans and transmission is thought to be via the faecal-oral route. In humans toroviruses have been found in infants with necrotising enterocolitis but their role in gastroenteritis remains unproved.…”

Section: Schistosoma Spindalementioning

confidence: 99%

Climate Change and Water-Related Infectious Diseases

Nichols

Lake²,

Heaviside

2018

Atmosphere

View full text Add to dashboard Cite

Background: Water-related, including waterborne, diseases remain important sources of morbidity and mortality worldwide, but particularly in developing countries. The potential for changes in disease associated with predicted anthropogenic climate changes make water-related diseases a target for prevention. Methods: We provide an overview of evidence on potential future changes in water-related disease associated with climate change. Results: A number of pathogens are likely to present risks to public health, including cholera, typhoid, dysentery, leptospirosis, diarrhoeal diseases and harmful algal blooms (HABS). The risks are greatest where the climate effects drive population movements, conflict and disruption, and where drinking water supply infrastructure is poor. The quality of evidence for water-related disease has been documented. Conclusions: We highlight the need to maintain and develop timely surveillance and rapid epidemiological responses to outbreaks and emergence of new waterborne pathogens in all countries. While the main burden of waterborne diseases is in developing countries, there needs to be both technical and financial mechanisms to ensure adequate quantities of good quality water, sewage disposal and hygiene for all. This will be essential in preventing excess morbidity and mortality in areas that will suffer from substantial changes in climate in the future.Atmosphere 2018, 9, 385 2 of 60 which do not suffer the consequences of extreme events to the same extent [4]. Due to the lifetime of greenhouse gases such as carbon dioxide in the atmosphere, and the timescales associated with ocean warming, even if global CO 2 emissions were curtailed immediately, the effects on the earth's climate, including increasing temperatures and sea level rise would continue for a number of decades before starting to plateau [2]. However, this should be seen as a general call to action to reduce emissions as soon as possible, given that the impacts are likely to extend beyond current conditions and there are indications that economic investment now will be likely to reduce costs later [5]. There is also a need to develop adaptations to cope with changes in climate. Recent research highlighting the health benefits of limiting future temperature rises to the more ambitious target of 1.5 • C rather than 2 • C, in line with the Paris agreement of 2016, further emphasises the need to limit emissions [6].Climate change affects health in a number of ways, and the impacts vary both geographically and between different populations. A growing and ageing population in much of the world means that the proportion of the population who are vulnerable to the effects of climate change will increase in the future [7]. The most direct impacts from climate change are from the effects of high temperatures, and from acute impacts relating to extreme events such as storms, floods and heatwaves. These physical or meteorological stressors can produce direct health effects, such as physical injury, illness, or mental health impacts du...

show abstract

A Waterborne Outbreak of Shigella sonnei with Resistance to Azithromycin and Third-Generation Cephalosporins in China in 2015

Cited by 31 publications

References 27 publications

Commensal Escherichia coli are a reservoir for the transfer of XDR plasmids into epidemic fluoroquinolone-resistant Shigella sonnei

Commensal Escherichia coli are a reservoir for the transfer of XDR plasmids into epidemic fluoroquinolone-resistant Shigella sonnei

Antibiotic Use in Agriculture and Its Consequential Resistance in Environmental Sources: Potential Public Health Implications

Climate Change and Water-Related Infectious Diseases

Contact Info

Product

Resources

About