A water-soluble polysaccharide from Eucommia folium: the structural characterization and anti-tumor activity in vivo

Yan, Zhiqian; Ding, Suyun; Chen, Pei; Liu, Huiping; Chang, Mengli; Shi, Shuyuan

doi:10.1007/s10719-022-10086-4

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…The aforementioned seven natural compounds all exert their anti-liver cancer effects by inducing apoptosis. Researchers have discovered that water-soluble polysaccharides extracted from Eucommia ulmoides leaves induce apoptosis via the mitochondrial pathway in H22 tumor-bearing mice [ 47 ]. The flavonoid compound lysionotin, upon acting on liver cancer cells and xenograft mouse models, enhances the expression levels of PARP, FasL, Bax, Bad, and cleaved caspases, while reducing the expression level of Bcl-xL.…”

Section: The Main Action Pathway and Potential Mechanism Of Natural C...mentioning

confidence: 99%

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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Liver cancer ranks third globally among causes of cancer-related deaths, posing a significant public health challenge. However, current treatments are inadequate, prompting a growing demand for novel, safe, and effective therapies. Natural products (NPs) have emerged as promising candidates in drug development due to their diverse biological activities, low toxicity, and minimal side effects. This paper begins by reviewing existing treatment methods and drugs for liver cancer. It then summarizes the therapeutic effects of NPs sourced from various origins on liver cancer. Finally, we analyze the potential mechanisms of NPs in treating liver cancer, including inhibition of angiogenesis, migration, and invasion; regulation of the cell cycle; induction of apoptosis, autophagy, pyroptosis, and ferroptosis; influence on tumor metabolism; immune regulation; regulation of intestinal function; and regulation of key signaling pathways. This systematic review aims to provide a comprehensive overview of NPs research in liver cancer treatment, offering a foundation for further development and application in pharmaceuticals and functional foods.

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Section: The Main Action Pathway and Potential Mechanism Of Natural C...mentioning

confidence: 99%

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Guo,

Yan,

Duan

et al. 2024

Nutrients

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“…Polysaccharides from Penthorum chinense Pursh have been shown to inhibit H22 cell growth via the induction of a mitochondrial-dependent apoptosis [15]. A water-soluble polysaccharide from Eucommia folium exhibited more potent toxicity on H22 cells [16]. Liu et al reported that an alcohol-soluble polysaccharide from Bletilla striata can significantly inhibit the growth of H22 cells at a certain concentration [17].…”

Section: Introductionmentioning

confidence: 99%

The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice

Tan

Liu

et al. 2023

Molecules

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Cordyceps has anti-cancer effects; however, the bioactive substance and its effect are still unclear. Polysaccharides extracted from Cordyceps sinensis, the fugus of Cordyceps, have been reported to have anti-cancer properties. Thus, we speculated that polysaccharides might be the key anti-tumor active ingredients of Cordyceps because of their larger molecular weight than that of polysaccharides in Cordyceps sinensis. In this study, we aimed to investigate the effects of wild Cordyceps polysaccharides on H22 liver cancer and the underlying mechanism. The structural characteristics of the polysaccharides of WCP were analyzed by high-performance liquid chromatography, high-performance gel-permeation chromatography, Fourier transform infrared spectrophotometry, and scanning electron microscopy. Additionally, H22 tumor-bearing BALB/c mice were used to explore the anti-tumor effect of WCP (100 and 300 mg/kg/d). The mechanism by WCP inhibited H22 tumors was uncovered by the TUNEL assay, flow cytometry, hematoxylin–eosin staining, quantitative reverse transcription–polymerase chain reaction, and Western blotting. Here, our results showed that WCP presented high purity with an average molecular weight of 2.1 × 106 Da and 2.19 × 104 Da. WCP was determined to be composed of mannose, glucose, and galactose. Notably, WCP could inhibit the proliferation of H22 tumors not only by improving immune function, but also by promoting the apoptosis of tumor cells, likely through the IL-10/STAT3/Bcl2 and Cyto-c/Caspase8/3 signaling pathways, in H22 tumor-bearing mice. Particularly, WCP had essentially no side effects compared to 5-FU, a common drug used in the treatment of liver cancer. In conclusion, WCP could be a potential anti-tumor product with strong regulatory effects in H22 liver cancer.

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Recent advances in natural polysaccharides against hepatocellular carcinoma: A review

Wang,

Zhang,

Zhao

et al. 2023

International Journal of Biological Macromolecules

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A water-soluble polysaccharide from Eucommia folium: the structural characterization and anti-tumor activity in vivo

Cited by 4 publications

References 51 publications

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

The Large Molecular Weight Polysaccharide from Wild Cordyceps and Its Antitumor Activity on H22 Tumor-Bearing Mice

Recent advances in natural polysaccharides against hepatocellular carcinoma: A review

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