A voxel‐based diffusion tensor imaging study in unipolar and bipolar depression

Repple, Jonathan; Meinert, Susanne; Grotegerd, Dominik; Kugel, Harald; Redlich, Ronny; Dohm, Katharina; Zaremba, Dario; Opel, Nils; Buerger, Christian; Förster, Katharina; Nick, Theresa; Arolt, Volker; Heindel, Walter; Deppe, Michael; Dannlowski, Udo

doi:10.1111/bdi.12465

Cited by 63 publications

(47 citation statements)

References 56 publications

(103 reference statements)

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“…These results are in agreement with previous findings of WMI deficits in BD when compared to either HV or MDD, although our results were limited to AD measurements. We did not find evidence that disruptions in AD in BD were related to cardiovascular risk factors, including CBF using ASL, in the BD group.…”

Section: Discussionmentioning

confidence: 88%

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Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

et al. 2019

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Objective:To compare white matter integrity (WMI) in bipolar disorder (BD) relative to healthy volunteers (HVs) and major depressive disorder (MDD). To determine the relationship of bipolar-specific differences in WMI to cerebral perfusion, body mass index (BMI), and blood pressure as indices of cardiovascular function.Methods: Thirty-two participants with BD, 44 with MDD, and 41 HV were recruited.All BD and MDD participants were in a major depressive episode, and all but 12 BD participants were medication-free. 64-direction diffusion tensor imaging (DTI) and arterial spin labeling (ASL) sequences were obtained. Tract-based spatial statistics (TBSS) on four DTI indices were employed to distinguish patterns of DTI in BD relative to HV and MDD groups. BMI, blood pressure, and medical histories were also obtained for the BD participants. Results:A cluster of lower axial diffusivity (AD) was found in BD participants in comparison to the HVs in the left posterior thalamic radiation, superior longitudinal fasciculus, inferior longitudinal fasciculus, fronto-occipital fasciculus, and internal capsule. Mean AD in the significant cluster was not associated with cerebral blood flow (CBF) in the region as measured by ASL, and was not associated with BMI or blood pressure. A cluster of lower AD was also found in the BD group when compared to MDD that had spatial overlap with the HV comparison. Conclusions:The results indicate a deficit of AD in BD when compared to MDD and HV groups. No association between AD values and either cerebral perfusion, BMI, or blood pressure was found in BD. K E Y W O R D S bipolar disorder, cerebral blood flow, diffusion tensor imaging, major depressive disorder, MRI How to cite this article: Lan MJ, Rubin-Falcone H, Sublette ME, et al. Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index. Bipolar

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Section: Discussionmentioning

confidence: 88%

“…Several studies also have reported more disruptions in WMI in BD when compared to major depressive disorder (MDD) using DTI, suggesting that WMI may be useful as a biomarker to distinguish the two disorders. Our third aim was to compare WM findings in BD to MDD.…”

Section: Introductionmentioning

confidence: 99%

Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

et al. 2019

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“…The CC, as the largest interhemispheric WM commissure, plays key roles in connecting the posterior commissures and anterior cerebral structure like the ACC and frontal lobe (Saito et al., ), involving information transmission between the PCC and the anterior cerebral hemisphere. Simultaneously disrupted WM connectivity in the PCC and CC was reported in bipolar depression patients when comparing with unipolar depression patients in a voxel‐based DTI study (Repple et al., ). We conjectured that abnormal structural connectivity in one brain region might thus provide a structural basis for abnormalities in the other region.…”

Section: Discussionmentioning

confidence: 93%

Cortical thickness and white matter integrity abnormalities in obsessive-compulsive disorder: A combined multimodal surface-based morphometry and tract-based spatial statistics study

Zhou

Ping

et al. 2018

Depress Anxiety

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“…Hence, a biomarker which can differentiate BD from SCZ could aid early initiation of prompt treatment and better outcomes. A few studies have suggested that brain morphometric measures are potential biomarkers to differentiate BD from HV and unipolar depression . Further studies are required to ascertain whether retinal imaging measures have similar potential as neuroimaging measures to be used as biomarkers.…”

Section: Discussionmentioning

confidence: 99%

Retinal vascular abnormalities in schizophrenia and bipolar disorder: A window to the brain

et al. 2019

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Objectives The examination of retinal microvascular abnormalities through fundus photography is currently the best available non‐invasive technique for assessment of cerebral vascular status. Several studies in the last decade have reported higher incidences of adverse cerebrovascular events in Schizophrenia (SCZ) and bipolar disorder (BD). However, retinal microvasculature abnormalities in SCZ and BD have remained under‐explored, and no study has compared this aspect of SCZ and BD till date. Methods Retinal Images of 100 SCZ patients, BD patients, and healthy volunteers each were acquired by trained individuals using a non‐mydriatic camera with a 40‐degree field of view. The retinal images were quantified using a valid semi‐automated method. The average of left and right eye diameters of the venules and arterioles passing through the extended zone between 0.5 and 2 disc diameters from the optic disc were calculated. Results The groups differed significantly with respect to average diameters of both retinal venules (P < 0.001) and retinal arterioles (P < 0.001), after controlling for age and sex. Both SCZ and BD patients had significantly narrower arterioles and wider venules compared to HV. There were also significant differences between SCZ and BD patients; patients with BD had narrower arterioles and wider venules. Conclusion Considering the affordability and easy accessibility of the investigative procedure, retinal microvascular examination could serve as a potential screening tool to identify individuals at risk for adverse cerebrovascular events. The findings of the current study also provide a strong rationale for further systematic examination of retinal vascular abnormalities in SCZ and BD.

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A voxel‐based diffusion tensor imaging study in unipolar and bipolar depression

Cited by 63 publications

References 56 publications

Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

Deficits of white matter axial diffusivity in bipolar disorder relative to major depressive disorder: No relationship to cerebral perfusion or body mass index

Cortical thickness and white matter integrity abnormalities in obsessive-compulsive disorder: A combined multimodal surface-based morphometry and tract-based spatial statistics study

Retinal vascular abnormalities in schizophrenia and bipolar disorder: A window to the brain

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